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Cerebral Ischemia

Editor: Ryszard Pluta, MD, PhD.

Editor Information
Brisbane (AU): Exon Publications; .
ISBN-13: 978-0-6450017-9-2

Cerebral ischemia is one of the most common causes of dementia, which develops in more than half of patients after an ischemic episode. The main mechanism is thought to be pathological changes in the hippocampus, especially in the CA1 area, underlying episodic memory impairment, which is the earliest and most important clinical symptom of post-ischemic dementia. The 13 chapters of this book present a new picture of ischemic brain disease, synthesizing the latest data on disease mechanisms, care for patients with this disease, and potential therapeutic targets. The authors present the characteristics of cerebral ischemia from pregnancy and childhood through adolescence to adulthood. The first two chapters provide a snapshot of the anatomy of the cerebral cortex and the hippocampus, the most affected brain structures after cerebral ischemia. This is followed by nine chapters that present a comprehensive view of the pathological mechanisms of cerebral ischemia, and how a deep understanding of these pathomechanisms hold the key for the discovery and development of novel therapies to help patients affected by cerebral ischemia. Chapter 12 shares real-life experience and challenges of rehabilitating patients into the community after cerebral ischemia, and chapter 13 analyzes the social risk variations, including gender inequality, in the reintegration of post-ischemic stroke patients. Although primarily aimed at scientists and clinicians, the contents of the book will be of interest to all those who are interested in cerebral ischemia, including patients and their caregivers.

Contents

Professor Ryszard Pluta, MD, PhD, is the head of the Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. He has held positions at the National Institutes of Health, Bethesda, USA, at the Institute for Basic Research in Developmental Disabilities, Staten Island, USA, and at the Max-Planck Institute for Neurological Research in Cologne, Germany. Professor Pluta was awarded by the Polish Association of Neuropathologists, President of Polish Academy of Sciences, Medical Secretary of Polish Academy of Sciences, Batory’s Foundation in Warsaw, Poland, International Brain Research Organization in Paris, France, and Alzheimer’s Association Chicago, USA. In 2017, Professor Pluta was awarded the Maria Curie-Skłodowska statuette. In New York in 1994 he was the first to propose the ischemic etiology of Alzheimer’s disease, followed by publications in which he presented proteomic and genomic alterations in the ischemic brain that are identical to those in Alzheimer’s disease. In 1998, he was the first to present autoimmunization as a new therapy for Alzheimer’s disease. Professor Pluta has published more than 250 peer-reviewed scientific articles and his current research focuses on developing ischemic model of Alzheimer’s disease. He is listed among the top 2% outstanding scientists in the world.

Cerebral Ischemia

ISBN: 978-0-6450017-9-2

DOI: https://doi.org/10.36255/exonpublications.cerebralischemia.2021

Edited by

Ryszard Pluta, MD, PhD, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland

Published by

Exon Publications, Brisbane, Australia

Copyright© 2021 Exon Publications

Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.

Notice to the user

The views and opinions expressed in this book are believed to be accurate at the time of publication. The publisher, editors or authors cannot be held responsible or liable for any errors, omissions or consequences arising from the use of the information contained in this book. The publisher makes no warranty, implicit or explicit, with respect to the contents of this book, or its use.

First Published in November 2021

Printed in Australia

Copyright© 2021 Exon Publications.

Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.

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