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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Pegloticase

Last Revision: August 16, 2021.

Estimated reading time: 1 minute

CASRN: 885051-90-1

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the use of pegloticase during breastfeeding. Because pegloticase is a very large molecule with molecular weight of 540,000 Da, and composed of smaller subunits with molecular weights of 34,000 Da, the amount in milk is likely to be low. Additionally, the drug is a protein that is likely to be partially digested in the infant’s gastrointestinal tract. It is unlikely that clinically relevant amounts reach the infant’s bloodstream. Studies with other pegylated drugs indicate that polyethylene glycol (PEG) is not excreted into breastmilk. Until more safety data become available, an alternate drug may be preferred.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Substance Identification

Substance Name

Pegloticase

CAS Registry Number

885051-90-1

Drug Class

Breast Feeding

Lactation

Antigout Agents

Gout Suppressants

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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