TABLE 10.1Summary for P2X Receptor Involvement in Acute and Chronic Pain

Cellular DistributionSelective AgonistAntagonistsPain InvolvementKey References
P2X3sensory neuronsATP, αβmeATPTNP-ATP
A-317491
Nociception: pain initiation and pain transmission, inflammatory and neuropathic painCockayne et al. 2000
Souslova et al. 2000
Jarvis et al. 2002
P2X4microgliaATPTNP-ATPChronic pain: neuropathic painTsuda et al. 2003
Ulmann et al. 2008
P2X7immune cellsATP
BzATP
A-438079
AZ-11645373
Chronic pain: inflammatory and neuropathic painChessell et al. 2005
Honore et al. 2006a

From: Chapter 10, On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory and Neuropathic Pain

Cover of Translational Pain Research
Translational Pain Research: From Mouse to Man.
Kruger L, Light AR, editors.
Boca Raton, FL: CRC Press/Taylor & Francis; 2010.
Copyright © 2010 by Taylor and Francis Group, LLC.

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