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Institute of Medicine (US) Forum on Microbial Threats. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington (DC): National Academies Press (US); 2006.

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Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary.

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APPENDIX AForum on Microbial Threats

Board on Global Health

Institute of Medicine

The National Academies

Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship

March 16–March 17, 2005

KECK 100

National Academies

500 Fifth Street, N.W.

Washington, D.C. 20001

AGENDA

WEDNESDAY, MARCH 16, 2005

8:30–9:00Continental Breakfast
9:00Welcome and Opening Remarks
Stanley Lemon, The University of Texas Medical Branch,
Galveston; Chair, Forum on Microbial Threats
9:15Arms Races with Evolving Diseases: “We’ve Met the Enemy and He Is Us”
Joshua Lederberg, Rockefeller University
Stanley Falkow, Stanford University
10:15Discussion
10:30Break

Session I. Host-Pathogen Interactions: Defining the Concepts of Pathogenicity, Virulence, Colonization, Commensalism, and Symbiosis

Moderator:P. Frederick Sparling, University of North Carolina
Vice-chair, Forum on Microbial Threats
10:45Colonization
Jeffrey I. Gordon, Washington University School of Medicine, or, Karen Guillemin, University of Washington
11:45Discussion
12:15Lunch—Welcoming Remarks by Dr. Harvey Fineberg, President, Institute of Medicine
1:00–2:30Commensalism and Symbiosis—Host, Microbial, and Environmental Factors
Abigail Salyers, University of Illinois, Champaign-Urbana
Jo Handelsman, Department of Plant Pathology, University of Wisconsin, Madison
2:30–2:45Discussion
2:45–3:00Break
3:00–4:15Pathogenicity and Virulence
Martin Blaser, New York University School of Medicine
BJ Staskawicz, University of California, Berkeley
4:15–5:45Open Discussion of Day 1
Moderator:David Relman, Stanford University
Balfor Sartor, University of North Carolina.
Maria G. Dominguez-Bello, University of Puerto Rico, Rio Piedras
5:45Adjournment of the first day
6:00Reception
7:15Dinner Meeting of the Forum on Microbial Threats
[location TBD]

THURSDAY, MARCH 17, 2005

8:00–8:30Continental Breakfast
8:30Opening Remarks/Summary of Day 1
P. Frederick Sparling, University of North Carolina
Vice-chair, Forum on Microbial Threats

Session II. Ecology of Host-Microbe Interactions

Moderator: Stephen S. Morse, Columbia University
8:40–9:25Endogenous Microbial Communities
David Stahl, University of Washington
Mark E.J. Woolhouse, Centre for Tropical Veterinary Medicine, University of Edinburgh
9:25–10:15How the Host “Sees” and Responds to Pathogens
Marian Neutra, Harvard Medical School and Children’s Hospital
David Relman, Stanford University
10:15–10:30Discussion
10:30–10:45Break

Session III. Understanding the Dynamic Relationships of Host-Microbe Interactions—Discussion Panel

Moderator:David Relman, Stanford University
10:45–12:15Lonnie King, Michigan State University
Stanley Falkow, Stanford University
Jeffrey I. Gordon, Washington University School of Medicine
12:15–12:45Lunch

Session IV. Novel Approaches for Mitigating the Development of Resistance

Moderator:James Hughes, Emory University
12:45–1:30Using Pre- and Probiotics to Modify Host-Environmental Factors to Promote Health and Mitigate Disease
Michiel Kleerebezem, Holland
Suzanne Cunningham-Rundles, Cornell University
1:30–2:00Governmental Approaches to Regulating Pre- and Probiotics
Lorenzo Morelli, Istituto di Microbiologia UCSC—Italy
Julienne Vaillancourt, CBER, FDA
2:00–2:15Discussion

Session V. Challenges and Opportunities to Developing a New Paradigm to Replace the “War Metaphor”

Moderator:Fredrick Sparling, University of North Carolina, Chapel Hill
2:15–4:00With the backdrop of the previous days’ presentations and discussion, Forum members, panel discussants, and the audience will comment on the issues and next steps that they would identify as priority areas for consideration within industry, academia, public health organizations, and other government sectors. The discussion of priorities will summarize the issues surrounding emerging opportunities for more effective collaboration as well as the remaining research and programmatic needs. The confounding issues of the major obstacles to pre- paring an optimal response, particularly as it relates to the complexities of inter- action between private industry, research and public health agencies, regulatory agencies, policy makers, academic researchers, and the public, will be explored with an eye toward innovative responses to such challenges.
Panel Discussants:
Joshua Lederberg, Rockefeller University
David Stahl, University of Washington
4:00Adjourn
Copyright © 2006, National Academy of Sciences.
Bookshelf ID: NBK57067

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