Liver tumors are a heterogeneous and complex mix of benign and malignant neoplasms that may arise in the setting of chronic liver injury or due to no prior insult. In children, hepatoblastoma is the most common malignant primary liver tumor and hepatocellular carcinoma is rare. In adults, however, hepatocellular carcinoma is most common and undifferentiated embryonal sarcoma is vanishingly rare. Liver Cancer explores these, and the myriad of other entities in between, with a depth and precision that is highly informative and practical to the modern physician scientist. Descriptions of grossing techniques, histopathologic features, ancillary testing modalities, molecular/genetic abnormalities, imaging characteristics, treatment options, clinical signs/symptoms and surgical approaches are contemporary contributions to this exciting field. Liver Cancer represents the latest knowledge of primary liver tumors. Refreshingly, it focuses on tumors and underlying processes that affect both children and adults. Written by and for practicing Pathologists, Oncologists, Surgeons, Gastroenterologists and Radiologists, its comprehensive content makes it a valuable reference for primary liver tumors.

Contents

• Foreword
• Preface
• List of Contributors
• 1. Carcinoma of the Liver in Children and Adolescents
  Consolato M. Sergi.
  • INTRODUCTION
  • HEPATOCELLULAR CARCINOMA
  • HEPATOCELLULAR ADENOMA AND FOCAL NODULAR HYPERPLASIA
  • LIPID-RICH HEPATOCELLULAR CARCINOMA
  • FIBROLAMELLAR CARCINOMA
  • PEDIATRIC METABOLIC CONDITIONS PREDISPOSING TO HEPATOCELLULAR CARCINOMA
  • CHOLANGIOCELLULAR CARCINOMA
  • CONCLUSION
  • REFERENCES
• 2. Hepatocellular Carcinoma in Adults
  Aducio L. Thiesen.
  • INTRODUCTION
  • ETIOLOGY AND PATHOGENESIS
  • NATURAL HISTORY AND PRE-NEOPLASTIC LESIONS
  • CLINICAL CHARACTERISTICS, DIAGNOSIS, AND DIAGNOSTIC TESTS
  • STAGING
  • TREATMENT
  • CONCLUSION
  • REFERENCES
• 3. Non-Alcoholic Fatty Liver Disease Progression to Non-Alcoholic Steatohepatitis-Related Primary Liver Cancer
  Utibe-Abasi Udoh, Juan D Sanabria, Pradeep K Rajan, Moumita Banerjee, Mathew Schade, Jacqueline A Sanabria, Gary Smith, Gideon Udoh, Komal Sodhi, Sandrine Pierre, Joseph I Shapiro, and Juan R Sanabria.
  • INTRODUCTION
  • EPIDEMIOLOGY
  • NAFLD PROGRESSION TO NASH-RELATED HCC
  • DIAGNOSIS AND STAGING OF HEPATOCELLULAR CARCINOMA
  • TREATMENT AND MANAGEMENT OF HCC
  • CONCLUSION
  • REFERENCES
• 4. Gross Dissection of Liver for Hepatocellular Carcinoma Using AJCC Cancer Staging Manual 8th Edition: Anatomical and Practical Considerations
  Marla Beach, Laura Henao Caviedes, and Consolato M. Sergi.
  • INTRODUCTION
  • GROSS AND SURGICAL ANATOMY OF THE LIVER
  • CONCLUSION
  • REFERENCES
• 5. Radiologic-Pathologic Correlation of Liver Tumors
  Eric Lachance, Jake Mandziuk, Consolato M. Sergi, Justin Bateman, and Gavin Low.
  • INTRODUCTION
  • HEPATOCELLULAR LESIONS
  • BILIARY LESIONS
  • VASCULAR MESENCHYMAL LESIONS
  • METASTATIC MALIGNANCIES
  • CONCLUSION
  • REFERENCES
• 6. Achieving a Cure: The Next Frontier in Hepatitis B Treatment
  Tina Boortalary, Brianna Shinn, Dina Halegoua-DeMarzio, and Hie-Won Hann.
  • INTRODUCTION
  • HBV LIFE CYCLE AND IMMUNOPATHOGENESIS
  • NATURAL HISTORY OF HEPATITIS B VIRUS AND CARCINOGENESIS
  • TREATMENT
  • ARE WE CLOSE TO ACHIEVING HBV CURE?
  • CONCLUSION
  • REFERENCES
• 7. Locoregional Therapies for Bridging and Downstaging Hepatocellular Carcinoma Prior to Liver Transplant
  Sandeep A. Ponniah, Andreas G. Zori, and Roniel Cabrera.
  • INTRODUCTION
  • EXPANDED TRANSPLANT CRITERIA
  • LOCOREGIONAL THERAPIES
  • CONCLUSION
  • REFERENCES
• 8. Hepatoblastoma
  Josef Hager and Consolato M. Sergi.
  • INTRODUCTION
  • ETIOLOGY
  • PATHOGENESIS
  • EPIDEMIOLOGY
  • SYMPTOMS
  • DIAGNOSTICS
  • THERAPEUTIC CONSIDERATIONS
  • FOLLOW-UP CARE
  • CONCLUSION
  • REFERENCES
• 9. Undifferentiated Embryonal Sarcoma of the Liver in Adults
  Jingyang Huang.
  • INTRODUCTION
  • CLINICAL PRESENTATION
  • RADIOLOGY
  • GROSS FEATURES
  • HISTOLOGY
  • IMMUNOHISTOCHEMISTRY
  • ELECTRON MICROSCOPY
  • MOLECULAR FINDINGS
  • PROGNOSIS AND TREATMENT
  • DIFFERENTIAL DIAGNOSIS
  • OTHER SARCOMAS
  • CONCLUSION
  • REFERENCES

Liver Cancer

ISBN: 978-0-6450017-2-3

DOI: https://doi.org/10.36255/exonpublications.livercancer.2021

Edited by

Consolato M. Sergi, MD, PhD, MPH, FRCPC, FCAP, Departments of Pediatrics, Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, Canada

Published by

Exon Publications, Brisbane, Australia

Copyright© 2021 Exon Publications

Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.

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First Published in April 2021

Printed in Australia