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Shekelle PG, Newberry SJ, Wu H, et al. Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Jun.

Cover of Identifying Signals for Updating Systematic Reviews

Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods [Internet].

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Appendix BSummary Tables

Cardiovascular Disease Risk Factors

Table B3. Updating effects of omega-3 fatty acids on cardiovascular disease risk factors

Table B4. Fish oil matrix, “RAND” versus “Ottawa” methods

Table B5. ALA matrix, “RAND” versus “Ottawa” methods

Of 6 experts, votes to not update outcomes:

Lipoprotein (a)1
Apolipoprotein A-11
Apolipoprotein B1
Apolipoprotein B-1002
LDL Apolipoprotein B1
Fasting insulin1
C reactive protein1
Fibrinogen3
Factor VII3
Factor VIII3
Exercise tolerance testing1
Heart rate variability1

From 6 experts, additional cardiovascular risk factors or intermediate markers suggested for updated report:

  • Cardiac arrhythmias (both atrial and ventricular)
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2).

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