NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Methylnaltrexone

Last Revision: November 16, 2020.

Estimated reading time: 1 minute

CASRN: 83387-25-1

image 391042346 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the use of methylnaltrexone during breastfeeding. The manufacturer recommends against breastfeeding in mothers taking methylnaltrexone. Based on pharmacokinetic data, the oral absorption of methylnaltrexone appears to be very low. Observe breastfed infants who have been exposed to opioids during pregnancy or postpartum for signs of opioid withdrawal, especially diarrhea.

Drug Levels

Based on the serum AUC values of oral and subcutaneous methylnaltrexone in the product labeling, it appears that methylnaltrexone has an oral bioavailability of <5%.

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Substance Identification

Substance Name

Methylnaltrexone

CAS Registry Number

83387-25-1

Drug Class

Breast Feeding

Lactation

Narcotic Antagonists

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...