Table 36Intervention, strength of evidence domains, and strength of evidence for key outcomes

InterventionDomains pertaining to Strength of Evidence (SOE):SOE
Risk of BiasConsistencyDirectnessPrecision
Adaptive behavior
Behavioral, UCLA/LovaasMediumConsistentDirectImpreciseLow
Adverse events/harms
Medical, Antipsychotics (Aripiprazole)LowConsistentDirectPreciseHigh
Medical, Antipsychotics (Risperidone)LowConsistentDirectPreciseHigh
ASDs symptom severity
Behavioral, UCLA/LovaasMediumInconsistentDirectPreciseLow
Medical, SecretinLowConsistentDirectPreciseHigh (lack of effectiveness)
Challenging behavior
Medical, Antipsychotics (Aripiprazole)LowConsistentDirectPreciseHigh
Medical, Antipsychotics (Risperidone)LowConsistentDirectPreciseModerate
IQ/cognitive
Behavioral, UCLA/LovaasMediumConsistentDirectPreciseLow
Medical, SecretinLowConsistentDirectPreciseHigh (lack of effectiveness)
Language/communication
Behavioral, UCLA/LovaasMediumConsistentDirectPreciseLow
Medical, SecretinLowConsistentDirectPreciseHigh (lack of effectiveness)
Repetitive behavior
Medical, Antipsychotics (Aripiprazole)LowConsistentDirectPreciseHigh
Medical, Antipsychotics (Risperidone)LowConsistentDirectPreciseModerate
Social skills/social behaviors
Medical, SecretinLowConsistentDirectPreciseHigh (lack of effectiveness)

ASDs=Autism Spectrum Disorders; SOE=strength of evidence; SRIs-selective serotonin reuptake inhibitors; UCLA=University of California, Los Angeles

From: Discussion

Cover of Therapies for Children With Autism Spectrum Disorders
Therapies for Children With Autism Spectrum Disorders.
Comparative Effectiveness Reviews, No. 26.
Warren Z, Veenstra-VanderWeele J, Stone W, et al.

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