NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Cover of Drugs and Lactation Database (LactMed)

Drugs and Lactation Database (LactMed) [Internet].

Show details

Ifosfamide

Last Revision: October 19, 2020.

Estimated reading time: 1 minute

CASRN: 3778-73-2

image 388353803 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as ifosfamide.[1] Labeling suggests that mothers should not breastfeed during therapy and for 1 week after the last dose of ifosfamide or mesna. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[1]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Pistilli B, Bellettini G, Giovannetti E, et al. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013;39:207–11. [PubMed: 23199900]
2.
Urbaniak C, McMillan A, Angelini M, et al. Effect of chemotherapy on the microbiota and metabolome of human milk, a case report. Microbiome. 2014;2:24. [PMC free article: PMC4109383] [PubMed: 25061513]

Substance Identification

Substance Name

Ifosfamide

CAS Registry Number

3778-73-2

Drug Class

Breast Feeding

Lactation

Antineoplastic Agents

Alkylating Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Views

Related information

Similar articles in PubMed

  • Review Decitabine[Drugs and Lactation Database (...]
    Review Decitabine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Gemcitabine[Drugs and Lactation Database (...]
    Review Gemcitabine
    . Drugs and Lactation Database (LactMed). 2006
  • Review Selinexor[Drugs and Lactation Database (...]
    Review Selinexor
    . Drugs and Lactation Database (LactMed). 2006
  • Review Denileukin Diftitox[Drugs and Lactation Database (...]
    Review Denileukin Diftitox
    . Drugs and Lactation Database (LactMed). 2006
  • Review Bleomycin[Drugs and Lactation Database (...]
    Review Bleomycin
    . Drugs and Lactation Database (LactMed). 2006
See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...