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Warren Z, Veenstra-VanderWeele J, Stone W, et al. Therapies for Children With Autism Spectrum Disorders. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Apr. (Comparative Effectiveness Reviews, No. 26.)

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Therapies for Children With Autism Spectrum Disorders.

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Appendix HQuality of the Literature

StudyGroup designRandom assignmentAppropriate comparisonRCT: Correct randomizationDSM-IV + ADI-R + ADOSDSM-IV + ADOS or ADI-R[DSM-IV + other] or [ADOS + other]Only DSM-IV or only ADOSNeither DSM-IV nor ADOSSample clearly characterizedInclusion/Exclusion criteria statedReported attritionDrop-out evaluated for differencesIntervention fully describedTreatment fidelity monitoredReported adherenceHeld steady concomitant interventionsReliability & validity of measuresPrim. & sec. measures specifiedData collected from approp. sourcesCoded by blinded individualsAppropriate statistical analysisIntent-to-treat analysisPower calculation providedCorrected for multiple testingConfounders & modifiers capturedConfounders & modifiers handledOutcomes measured outside tx settingOutcomes measured in natural environ.Follow-up at least 3 mos post-txFinal Score
Adams 2009{, #5813;, #5727}++N+++++++++NN+++++P
Akhondzad eh 2004{, #857}++++++++N+N++++++NNN++F
Akhondzad eh 2008{, #250}+++++++N+N++++++++NNNF
Akhondzad eh 2010{, #5879}++++++NN+N++++++NNN+F
Aldred 2004{, #803}++++++++N+++++++NNN++F
Allam 2008{, #170}+++++++N++++++++NNNF
Aman 2009{, #5657}++++++++++++++++NNN++F
Anan 2008{, #2542}N++++++++NNN++P
Andersen 2008{, #192}N+++N+N++++NNN+++++P
Arick 2003{, #2853}N+++N+++++NNN++P
Baker-Ericzen 2007{, #2629}N++++++++NN+++++P
Bass 2009{, #5609}++++++++++NNN++P
Bauminger 2006{, #422}NN+++++++++++NNNN+F
Bauminger 2006{, #423}NN++++N++++++NNNN+F
Beaumont 2008{, #125}+++++++N+++++NNN+++P
Beglinger 2005{, #670}N++++++++++NNNN++F
Ben-Itzchak 2007{, #538}N++++N++++NNNN+P
Bibby 2002{, #1065}N+++++++++NN+++++P
Boyd 2001{, #1121}N++++++++NNNN++P
Carmody 2001{, #1226}N+NN+++++NNP
Carr 2008, 2007{, #165;, #462}+++++++N++++++NNNN+P
Chalfant 2006{, #387}++++++++++++NNN++P
Chan 2009{, #5606}++++++N++++NNN++P
Chez 2000{, #1271}N+++N+N+++++NN+N++P
Chez 2002{, #988}++++++++N+N++++++N+NN++F
Chez 2003{, #2844}+++++++++N+++++NNN++F
Chez 2004{, #850}+++N+N+++++NNN++P
Coben 2007{, #2636}++N++N++++++NN+++++P
Cohen 2006{, #546}++N++++++++++NNNN++F
Coniglio 2001{, #1201}+++++++++N++++++NN++F
Corbett 2007{, #297}++++++N+++++NNNNF
Correia 2009{, #6120}NN+++++N+++NN++++P
Cotugno 2009{, #5071}+N++++N++++NN++++F
Dawson 2010{, #5715}+++++++++++++++NNN++G
Delong 2002{, #1020}N+++N+N+NNNP
Dillenburge r 2004{, #2797}N++++NNNN++P
Dosman 2007{, #347}NN+++++++++NNN++++P
Drew 2002{, #997}++++++++N+++++++NNN++F
Dunn-Geier 2000{, #1232}++++++++N+N++++++++NN++F
Eikeseth 2002, 2007{, #1117;, #328}++N+++++++++++NNNN+++F
Eikeseth 2009 & Hayward 2009{, #5680;, #3630}+N+++++++++++++NN++++F
Eldevik 2006{, #588}++N++++++++NNN+++P
Escalona 2001{, #1120}++++++N+N+++++NNN++P
Escalona 2002{, #4810}++++++N+++++++NNNP
Evangeliou 2003{, #970}N++++++++NNNNN+P
Farrell 2005{, #4808}++N++++++NNN++P
Fazlioglu 2008{, #118}+++++++N++++++NNNNP
Field 2001{, #1135}++++++N++++++NNNP
Frankel 2010{, #5826}+++++++++++++NNN++F
Gabriels 2001{, #1122;, #3842}N+++++++++N++++++P
Gevers 2006{, #569}N+NN+++NNN++P
Golan 2010{, #5892}+++++++++++++N+NN++P
Granpeesh eh 2009{, #5717}NN+++NN++++NNNNP
Green 2010{, #6090}++++++++++++++++++NNN++F
Greenberg 2008{, #3784}NN+NN+++++NNNN++P
Grey 2005{, #664}N++N+++NNNN++P
Gulsrud 2007{, #2578}+++++++++++++NNN+P
Gulsrud 2010{, #5893}N++++++++++NN++++F
Gutstein 2007{, #246}NN+++N++++++NN+++++P
Handen 2009{, #4350}++++++++N+++++++++NN++G
Harris 2000{, #1270}N++++N++++NNN+++++P
Hartshorn 2001{, #3016}++N++N+++++NNNN+P
Heimann 2006{, #2677}++++++N++++++NNNP
Henry 2006{, #578}N++NN+N++++NNNNNP
Hollander 2005{, #777}++++++++N+++++++NNN++F
Howard 2005{, #734}++N+++++++++NN+++F
Howlin 2007{, #312}++++++++++++++NN+P
Itzchak 2008{, #252}+++++++NNNNP
Itzchak 2009{, #3844}NN+++N+++++NN++++P
Jarusiewic z 2002{, #2953}+++N+++N++++NNN++P
Jung 2006{, #2698;, #4951}+N+++N++++NNNP
Kasari 2006, 2008{, #540;, #184}+++++++++++++++NNN+++F
Keen 2007{, #383}NN++N+++NNNN+P
Kern 2001{, #1208}++++++++N+++++NN++F
Kim 2008, 2009{, #106;, #4314}++++++++++NNN++P
King 2001{, #1192}+++++++N+N+++++++NNN++F
King 2009{, #4321}+++++++++N+++++++++NN+G
Kroeger 2007{, #3901}+++++++++++NNNP
Laud 2009{, #5744}NN+++++++NNN+++P
Legoff 2006{, #5558}++N+++NN+++++NN++++P
Levy 2003{, #942}++++++++++N+++++NN++F
Lopata 2006{, #2697;, #216}N+++N++++++NNN++P
Lopata 2008{, #216;, #2697}+++++++N++++++++NNN++F
Ludlow 2006{, #5711}N+++N+++++NN++P
Ludlow 2008{, #3710}NN++N++++NNN+P
Luiselli 2000{, #3024}N+N+++++NN++++P
Magiati 2003{, #916}N+++N++++++NN+NN+P
Magiati 2007{, #288}++N++++N++++++N++++F
Mahoney 2005{, #719}N+++N++++++NNNN+P
Marcus 2009{, #5687}++++++++N++++++++NNN++G
Masi 2003{, #891}N+++++N++++NN+NN+P
McConachie 2005{, #651}++N++++N+++++++++NNNN++F
Meguid 2008{, #107}+N+++N++++++NNNN++P
Molloy 2002{, #995}++++++++N+++++++NN++F
Moore 2000{, #1253}+++++N++++++++NNNN+P
Mousain-Bosc 2006{, #508}N++N+N+++++NNNNP
Mudford 2000{, #1228}+N+++++++++NNNN+++F
Mukaddes 2004{, #855}N++N+++++NNNN+P
Munasingh e 2010{, #5843}++++++++N+++++++NN++F
Nagaraj 2006{, #475}+++++++++N+++++NNN++F
Nickels 2008{, #130}NN++NN++++NNN++++NP
Osborne 2008{, #224}++N++++N++++++NN+++F
Owen 2009{, #5714}++++++++N++++++++NNN++G
Owens 2008{, #116}++++++++++++NNN++P
Owley 2001{, #1142}++++++++N+N+++++++++NN++G
Owley 2010{, #5841}N+++++N+++++NNN++++F
Pan 2010{, #6030}NN++NN++++++NN+N++P
Panerai 2009{, #4343}++N++++N+++++NNN++G
Perry 2008{, #3668}NN+++NN+++++NN++++P
Piravej 2009{, #6031}+++++++++++NNN++P
Posey 2004{, #821}N+++NN+N+++++NNN++NP
Probst 2008{, #158}N++++N++++NNN+P
Quirmbach 2009{, #84}+++++++N+++++++NNN++F
Reaven 2009{, #3650}++N+++++++++++NNNN++F
Reed 2006{, #381}++N++++N++++++NNN+F
Reed 2007{, #3887}++N+++++++++NN++++F
Reed 2009{, #5066}NN+++++++++NNN++P
Reed 2010{, #5899}++N++++N+++++++NN++++F
Remington 2007{, #240}++N+++N+++NN+++P
Rickards 2001{, #278}+++++++++++++NNN+G
Roberts 2001{, #1199}+++++++++N+++++++NN++G
Rossignol 2009{, #4}++++++++++++++++++NNN++G
RUPP 2002{, #1051;, #610;, #704;, #892;, #564;, #539;, #108;, #838;, #691}+++++++++++++++++++NNNG
RUPP 2005; Posey 2007; Jahromi 2009{, #635;, #363;, #3615}+++++++++N+++++++NNN++F
RUPP 2005{, #5725}NN++++++++++++NNN++G
Sallows 2005{, #647}++++++++++++++++NNN+++G
Salt 2002{, #1094}++N++++++++NNN++P
Sams 2006{, #532}+N++N++++NNNN+P
Shea 2004; Pandina 2007{, #799;, #458}++++++++N++++++++NNN++F
Silva 2007{, #302}+++++++++++++NNN+F
Silva 2008{, #58}NN+++N++++++NNN+P
Silva 2009{, #5051}+++++++++++N+NN+++P
Smith 2000{, #1264}+++++++N+++++++++N+NN++F
Sofronoff 2002{, #1039}++N+N++++NN+N++P
Sofronoff 2003{, #5832}+++++N++++++NNNN++P
Sofronoff 2004{, #814}+++++N+++++NNN++P
Sofronoff 2005{, #644}++++++++++++++N+NN++F
Sofronoff 2007{, #417}+++++++N++++++++NNN++F
Solomon 2004{, #756}+++++++N++++++NNN++F
Solomon 2007{, #3950}NN+++++++++NNN++P
Solomon 2008{, #150}+++++++N+++++++NNNN++F
Stahmer 2001{, #2999}++N+++N+++++++NNN++P
Stahmer 2004{, #4234}NN++++N+++++NNN++P
Stigler 2004{, #845}N++NN+N++++NNNN++P
Tjus 2001{, #1141}N+++N++++++NN+++P
Tsang 2006{, #491}+N++++N++++NNNN+F
Tyminski 2008{, #2539}N+++++++++NN++++P
Unis 2002{, #1024}++++++++N++++NN++F
Vismara 2009{, #5767}NN++++++++++NNN++P
Vorgraft 2007{, #245}N++NN++++NN+N++P
Wetherby 2006{, #4027}NN++++N+++++NNN++P
Whalen 2010{, #6122}+++++++N+++++NNN+P
Whitaker 2004{, #4176}NN+++N++++NNNN+P
Whittingha m 2009{, #3592;, #3631}+++++++++++++N+NN+++P
Wong 2007{, #3875}N++++N++++++NN+++P
Wood 2009{, #3618;, #5523}++++++++++++++++NNN+++F
Yoder 2006, 2009{, #516;, #487;, #5719;, #408}++++++++N+++++++++NNN++G
Zachor 2007{, #5652}++N+++N+++++NN++F

+ = Yes, − = No or Not Reported, and N = Not applicable

G = Good, F = Fair, and P = Poor

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