Table 14Strength of Evidence for articles being addressed by Key Question 4

OutcomeNumber of Studies; SubjectsRisk of Bias Design/QualityConsistencyDirectnessPrecisionStrength of Evidence
Death6; 1444RCT/ fairConsistentDirectImpreciseModerate
2; 57Cohort/poor
Death or BPD6; 1529RCT/ fairInconsistentDirectImpreciseLow
Death or NDI3; 851RCT/ fairConsistentDirectImpreciseLow
BPD at 36 weeks4; 1321RCT/ goodConsistentDirectImpreciseModerate
BPD not defined1; 18Cohort/fairUnknownIndirectImpreciseLow
Severe BPD, Mechanical vent (survivors)1; 16Cohort/fairUnknownDirectImpreciseLow
On O2 at 1 year1: 502RCT/GoodInconsistentDirectImpreciseLow
Survival without BPD2; 790RCT/ fairConsistentDirectImpreciseModerate
Survival to discharge1; 41Cohort/ poorUnknownDirectImpreciseLow
Survival > 28 days1; 18Cohort/fairUnknownDirectImpreciseLow
Survival with BPD1; 208RCT/goodUnknownDirectImpreciseLow
Cerebral palsy1; 31Cohort/ fairUnknownDirectImpreciseLow
Neuro-developmental Index-related outcomes5; 1442RCT/ goodInconsistentDirectImpreciseLow
Severe IVH (3-4) or PVL1; 420RCT/ goodUnknownDirectImpreciseLow

BPD = bronchopulmonary dyplasia; NDI = neurodevelopmental impairment; IVH = intraventricular hemorrhage; PVL = periventricular leukomalacia

From: 4, Discussion

Cover of Inhaled Nitric Oxide in Preterm Infants
Inhaled Nitric Oxide in Preterm Infants.
Evidence Reports/Technology Assessments, No. 195.
Allen MC, Donohue P, Gilmore M, et al.

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