Structured Abstract

Contents

• Preface
• Acknowledgments
• Executive Summary
• 1. Introduction
  • Background
  • Purpose of This Evidence Report
  • Key Questions
• 2. Methods
  • Topic Development
  • Analytic Framework
  • Search Strategy
  • Study Selection
  • Data Abstraction
  • Quality Assessment of Individual Studies (Risk of Bias Assessment)
  • Grading of the Body of Evidence
  • Data Synthesis
  • Peer Review
• 3. Results
  • Literature Search/Abstract/Article Review
  • Description of the Types of Studies Retrieved
  • Risk of Bias
  • Key Question 1 Does inhaled nitric oxide (iNO) therapy increase survival and/or reduce the occurrence or severity of bronchopulmonary dysplasia (BPD) among premature infants who receive respiratory support?
  • Key Question 2 Are there short term risks of iNO therapy among premature infants who receive respiratory support?
  • Key Question 3 Are there effects of iNO therapy on long term pulmonary and/or neurodevelopmental outcomes among premature infants who receive respiratory support?
  • Key Question 4 Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary across subpopulations of premature infants?
  • Key Question 5 Does the effect of iNO therapy on BPD and/or death or neurodevelopmental impairment vary by timing of initiation, mode of delivery, dose and duration, or concurrent therapies?
• 4. Discussion
• 5. Future Research
  • Other Future Research Needs
• References and Included Studies
• Appendixes
  • Appendix A List of Acronyms
  • Appendix B Detailed Electronic Database Search Strategies
  • Appendix C Screen and Data Abstraction Forms
  • Appendix D List of Excluded Articles
  • Appendix E Evidence Tables

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290-2007-10061-I. Prepared by: The Johns Hopkins University Evidence-based Practice Center, Baltimore, MD

Suggested citation:

Allen MC, Donohue P, Gilmore M, Cristofalo E, Wilson RF, Weiner JZ, Bass EB, and Robinson K. Inhaled Nitric Oxide in Preterm Infants. Evidence Report/Technology Assessment No. 195. (Prepared by Johns Hopkins University Evidence-based Practice Center under Contract No. 290- 2007-10061-1). AHRQ Publication No. 11-E001. Rockville, MD: Agency for Healthcare Research and Quality. October 2010.

This report is based on research conducted by the Johns Hopkins University Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2007-10061-I). The findings and conclusions in this document are those of the author(s), who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.

This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

No investigators have any affiliations or financial involvement (e.g., employment, consultancies, honoraria, stock options, expert testimony, grants or patents received or pending, or royalties) that conflict with material presented in this report.

1

540 Gaither Road, Rockville, MD 20850; www​.ahrq.gov.