Compoundaq. Kinetic sol. (PBS @ pH 7.4)Caco-2 (Papp 10−6 m/s @ pH 7.4)efflux ratio (B→A)/(A→B)mouse liver microso me stability (T1/2)PBS-pH 7.4 Stability: % remaining after 48hMouse plasma stability:% remaining after 48h
NCGC0003785035.9μM210.68< 10min.10098

Note: kinetic solubility analyses was performed by Analiza Inc. and are based upon quantitative nitrogen detection as described (www​.analiza.com). The data represents results from three separate experiments with an average intraassay %CV of 4.5%. LogD analysis was performed by Analiza Inc. and are based upon octanol/buffer portioning and quantitative nitrogen detection of sample content as described (www​.analiza.com). All other data were conducted at Pharmaron Inc.

From: Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.