Figure 7. Mechanism-of-action studies of probe compound with respect to the substrate.

Figure 7Mechanism-of-action studies of probe compound with respect to the substrate

Insets show the Michaelis-Menten graphs of 15-PGDH activity at increasing concentrations of PGE2, while the main graphs show plots of the data after Lineweaver and Burk. Dotted lines in both representations show fits to the Michaelis equation. Black represents no inhibitor, blue denotes 10nM probe compound, and red denotes 50nM probe compound.

From: Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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