Table 3SAR Analysis for T. cruzi

SAR Analysis for T. cruzi
Image ml158fu13.jpg
Potency (μM) mean ± S.E.M. (n=replicates)Target to Antitarget Fold Selectivity
EntryCIDSIDBroad No.*RR′nT. cruzi inhibitionnToxicity
14689791699351067BRD-A04542699P
Image ml158fu14.jpg
Image ml158fu15.jpg
30.763 ±0.0413352.7 ±19.969
Solubility: NDPurity: 91%
2420791887556801BRD-A99518825P
Image ml158fu16.jpg
Image ml158fu17.jpg
31.01 ±0.6553inactive>500
Solubility: >500 μMPurity: 93%
3993510723422467BRD-A36791463P
Image ml158fu18.jpg
Image ml158fu19.jpg
33.54 ±2.12341.7 ±6.9612
Solubility: 388.9 μMPurity: 88%
4875567952838441BRD-A98050686S
Image ml158fu20.jpg
Image ml158fu21.jpg
39.91 ±3.673164 ±53.117
Solubility: >500 μMPurity: 85%

ND= Not determined;

*

P = Purchased; S = Synthesized

From: Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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