Table 1Investigation of SAR around aryl ring

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EntryArInternal IDaCIDSIDIC50 (nM)b
1
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NCGC-0018343444620939875441730.47
2
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NCGC-0024107046916205993808120.424
3
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NCGC-0024106946916204993808112.09
4
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NCGC-0024107346916207993808140.44
5
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NCGC-0024107146916206993808135.36
a

All compounds synthesized at NCGC

b

IC50 values were determined at NCGC utilizing a fluorescent enzyme assay using the appropriate AFC-labeled peptide.

From: A small molecule inhibitor of Caspase 1

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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