Scheme 2, Analog synthesis - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf

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Scheme 2. Analog synthesis.

Scheme 2Analog synthesis

Reagents and conditions: (i) DMC, DIPEA, r.t. 12 h; (ii) ACN, r.t.-50 °C. (iii) K₂CO_3, DMA, microwave heating, 150 °C, 10 min; (iv) Yb(OTf)₃, DMA, microwave heating, 200 °C, 10 min; (v) DDQ, r.t. 1 h

From: Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists

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Probe Reports from the NIH Molecular Libraries Program [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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