Table 1SAR Analysis and Properties of 4-substituted Quinazoline Analogues

SAR AnalysisStructure
Image ml134fu2.jpg
Target Potency (μM)Anti-target Potency(μM)Selectivity**
EntryCIDSIDBroad ID*RIC50 _SKexpIC50 _ViabilitySelectivity
1161203899432327BRD-K58698715-001-07-8S-OMe4.2inactive4.2_vs_inactive
Solubility (PBS): <1 μM; Plasma Protein Binding (Human, Mouse): 97.7 %, 98.2%; Plasma Stability (Human, Mouse): 63.6 %, 90.0%; Purity(UPLC): 100%
24692584699430883BRD-K96365082-001-01-6S-OHinactiveinactiveinactive_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
34692582799430895BRD-K48925654-001-01-4-OnPr30.0inactive30.0_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
44692582599430885BRD-K18605675-001-01-3S-OiPrinactive15inactive _vs_15
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
54692585099430889BRD-K97026879-001-01-0S-OCH2CH2CH2Meinactiveinactiveinactive_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
64692658099432326BRD-K47972308-001-01-7S-OCH2CH2CH2OMe9.1inactive9.1_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
74692583899430900BRD-K38499282-001-01-2S-OCH2CMe3inactive19inactive _vs_19
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
849843280104170256BRD-K37774108-001-01-1S-NHMe11.0322.9
Solubility (PBS): <1.0 μM; Purity(UPLC): 99%
949843163104170245BRD-K26931579-001-01-0SNMe237.0inactive37.0_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 99%
10159703787334023BRD-K80942107-001-01-1P
Image ml134fu3.jpg
inactiveinactiveinactive _vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 99%
11160320299430876BRD-K15164035-001-01-9S
Image ml134fu4.jpg
45.0inactive45.0_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100%
124692584899430901BRD-K10723844-001-01-8S
Image ml134fu5.jpg
16.0inactive16.0_vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 99%
13163473287334028BRD-K42568865-001-01-3P
Image ml134fu6.jpg
inactiveinactiveinactive _vs_inactive
Solubility (PBS): <1.0 μM; Purity(UPLC): 100 %

P = Purchased;

*

S = synthesized;

**

Selectivity = IC50_Viability/IC50_SKexp

From: Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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