Table 4SAR of selected thieno[3,2-b]pyrrole[3,2-d]pyridazinones

Image ml170fu8.jpg
EntryInternal IDaSIDCIDR′R″hPykM 2 AC 50 (μM)b
1NCGC001826265764626425243749Methyl2,3-difluoro-4-methylbenzyl0.057
2NCGC001826285764626525243750Methyl2,4-difluorobenzyl0.025
3NCGC001826299937659946912194Methyl2,5-difluorobenzyl0.631
4NCGC001826375764626825243753Methyl2,6-difluorobenzyl0.025
5NCGC001826425764626925243754Methyl2-chloro-6-fluorobenzyl0.040
6NCGC001826455764627025243755Methyl2,3-difluorobenzyl0.113
7NCGC001826465764627125243756Methyl2,3,4-trifluorobenzyl0.713
8NCGC001826319937660046912195Methyl2,4,5-trifluorobenzyl0.355
9NCGC001826239937659646912191Methyl3-chloro-2-fluorobenzyl0.447
10NCGC001826259937659746912192Methyl6-chloro-2-fluoro-3-methylbenzyl1.120
11NCGC001827849943107516670259Methyl3-methoxybenzyl0.282
12NCGC001827829943107446925942Methyl3-trifluoromethylbenzyl1.780
13NCGC001827809943107346925941Methyl3-methylbenzyl0.631
14NCGC001827745764627725243761Methyl3-chlorobenzyl0.794
15NCGC00031955851783654376Methyl2-fluorobenzyl0.130
16NCGC001824125764625625243741S(O)Me2-fluorobenzyl0.025
17NCGC001865278526788444246498S(O)Me3-methoxybenzyl0.073
18NCGC001865288526788544246499S(O)Me3-(methyl)aniline0.092
19NCGC001877498722572044543627S(O)Me3-(methyl)phenol0.041
a

All compounds synthesized at NCGC

b

AC50 values were determined utilizing the luminescent pyruvate kinase-luciferase coupled assay.

From: Identification of activators for the M2 isoform of human pyruvate kinase Version 3

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.