Table 3SAR of selected N,N-bisarylsulfonamides

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entryInternal IDaCIDSIDnAr1Ar2hPyk, M2
AC50 (mM)b
1NCGC0003033565036184794314-methoxybenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.562
2NCGC00181063252437165764621812,4,5-trifluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.708
3NCGC00181075469258599943093012-trifluoromethoxybenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)1.00
4NCGC00182418445435778722566214-bromo-2,5-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)4.47
5NCGC00182431445435878722567214-carboxlic acid-2,5-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)15.8
6NCGC00182435445435908722567614-(carboxymethyl)-2,5-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)17.8
7NCGC00182423252437455764626014-(nPropyl)-2,5-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)31.6
8NCGC00182430445435868722567114-Me-carboxylate-2,5-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.224
9NCGC00182834162720099943093113-carboxylic acid benzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.355
10NCGC00168675252437095764620913-methoxybenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.447
11NCGC00182822252437725764628912,6-difluorophen-3-ol6-(2,3-dihydrobenzo[b][1,4]dioxine)0.562
12NCGC00182825252437735764629012,6-difluoro-4-methoxybenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)1.00
13NCGC0016868725243713576462141benzene6-(2,3-dihydrobenzo[b][1,4]dioxine)1.21
14NCGC00182833252437775764629513-trifluoromethyl6-(2,3-dihydrobenzo[b][1,4]dioxine)1.26
15NCGC00181059252437155764621612,4-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)1.58
16NCGC00181061252104935764621712,6-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.065
17NCGC00l82829252437755764629222,6-difluorobenzene6-(2,3-dihydrobenzo[b][1,4]dioxine)0.866
18NCGC00l85917445436068722569513-aniline6-(2,3-dihydrobenzo[b][1,4]dioxine)0.023
19NCGC00l85919445436088722569713-aniline6-(2,3-dihydrobenzo[b][1,4]dioxine)0.041
20NCGC00185921445436098722569913-aniline2,6-difluorobenzene0.092
21NCGC00185923445436118722570123-aniline2,6-difluoro-4-methoxybenzene0.206
22NCGC00l85916445436058722569423-aniline6-(2,3-dihydrobenzo[b][1,4]dioxine)0.033
a

All compounds synthesized at NCGC

b

AC50 values were determined utilizing the luminescent pyruvate kinase-luciferase coupled assay

From: Identification of activators for the M2 isoform of human pyruvate kinase Version 3

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