From: Vaccine Development: Current Status and Future Needs
Copyright 2005 American Academy of Microbiology.
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Vaccine Development: Current Status and Future Needs: This report is based on a colloquium, sponsored by the American Academy of Microbiology, held March 4-6, 2005, in Washington, DC. Washington (DC): American Society for Microbiology; 2005. doi: 10.1128/AAMCol.4Mar.2005
Vaccine Development: Current Status and Future Needs: This report is based on a colloquium, sponsored by the American Academy of Microbiology, held March 4-6, 2005, in Washington, DC.
Show detailsTABLE 4.Vaccines removed from the market
| VACCINE | COMMENTS |
|---|---|
| SMALLPOX | SMALLPOX ERADICATED |
| ORAL POLIO (OPV) | POLIO REGIONALLY ELIMINATED A SAFER VERSION (INACTIVATED POLIO VACCINE) WAS AVAILABLE THAT REPLACED THE LIVE ATTENUATED ORAL VACCINE IN INDUSTRIALIZED COUNTRIES |
| ROTAVIRUS (ROTASHIELD®) | SAFETY CONCERNS (IMPLICATED AS A CAUSE OF INTUSSUSCEPTION IN INFANTS) |
| LYME DISEASE | SAFETY CONCERNS (REAL AND/OR PERCEIVED AUTOIMMUNE SIDE EFFECTS) |
| ECONOMIC REASONS (ACTUAL MARKET PROVED MUCH SMALLER THAN ORIGINALLY ANTICIPATED, EXPENSIVE LITIGATION) | |
| ADENOVIRUS | ECONOMIC REASONS (THE COSTS OF ADHERING TO NEW GOOD MANUFACTURING PRACTICE RULES WERE PROHIBITIVE FOR THE MANUFACTURER) |
| HEPATITIS B (PLASMA-DERIVED) | PERCEIVED SAFETY RISKS (HUMAN PLASMA WAS SEEN AS UNSAFE FOR VACCINE PRODUCTION IN THE WAKE OF THE DISCOVERY OF AIDS IN THE 1980S) REPLACED BY AN IMPROVED PRODUCT (RECOMBINANT HBV VACCINE) |
| HBV RECOMBINANT | SUSPENDED FROM USE IN SCHOOL-AGED CHILDREN IN FRANCE PERCEIVED SAFETY RISKS (UNSUBSTANTIATED LINKS TO MULTIPLE SCLEROSIS) |
| WHOLE CELL PERTUSSIS | REMOVED FROM THE MARKET IN SWEDEN BECAUSE OF SAFETY CONCERNS (REPLACED IN OTHER MARKETS WITH THE ACELLULAR PERTUSSIS VACCINE) |
| KILLED MEASLES | SAFETY CONCERNS (ATYPICAL MEASLES) |
| HIB POLYSACCHARIDE | REPLACED BY AN IMPROVED PRODUCT (HIB CONJUGATE VACCINE) |
| NEURAL TISSUE-DERIVED RABIES | REPLACED BY AN IMPROVED PRODUCT (CELL CULTURE-DERIVED VACCINE) |
| INTRANASAL INACTIVATED INFLUENZA (ADJUVANTED WITH WTLT) | SAFETY CONCERNS (BELL'S PALSY) |
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- TABLE 4. Vaccines removed from the market - Vaccine Development: Current Status ...TABLE 4. Vaccines removed from the market - Vaccine Development: Current Status and Future Needs
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