TABLE 4-12Vitamin D and Bone Health: Characteristics of RCTs Published after AHRQ-Ottawaa

Reference; Location (Latitude)PopulationDescriptionBackground Calcium Intake and Vitamin D DataComparisonsCompliance
Lyons et al., 2007

South Wales, UK (52°N)
Health status

Mean age (range), y
Male (%)
Living in care facilities including some elderly with mobility, cognitive, visual, hearing, or communication impairments 84 (62–107)

23.7
nd100,000 IU vit D2 4× monthly vs. placebo80% (percentage of occasions observed to take tablets)
Burleigh et al., 2007

Scotland (55°57'N)
Health status

Mean age (SD), y
Male (%)
Inpatient with high levels of comorbidity, mortality, and polypharmacy 83 (7.6)

40
25OHD: 22 nmol/L800 IU vit D3/d + 1,200 mg Ca carbonate/d vs. 1,200 mg Ca carbonate/dCa group = 87%, vit D + Ca group = 89% (total study drug taken/total study drug prescribed, as recorded in drug prescription charts)
Bunout et al., 2006

Chile (32°S)
Health status
Mean age (SD), y
Male (%)
Healthy

76 (4)

11.6
25OHD: ≤ 40 nmol/L800 mg Ca/d vs. 800 mg Ca/d + 400 IU vit D/d (with and without exercise training)92% (tablet counting)

NOTE: IU = International Units; nd = not determined; SD = standard deviation; UK = United Kingdom; vit = vitamin; y = year(s)

a

This table has been truncated for the purposes of this chapter, but it can be found in its entirety in Appendix D.

SOURCE: Modified from Chung et al. (2009).

From: 4, Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D

Cover of Dietary Reference Intakes for Calcium and Vitamin D
Dietary Reference Intakes for Calcium and Vitamin D.
Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al., editors.
Washington (DC): National Academies Press (US); 2011.
Copyright © 2011, National Academy of Sciences.

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