TABLE 4-11Odds Ratio (95% Confidence Interval) for Total Fractures from Individual RCTs of Vitamin D: Summary from AHRQ-Ottawa Analysesa

Reference; Jadad Score for RCTsbDuration (y)Sample Size (n)Vitamin D (IU/day) Follow-upMean Baseline 25OHD for IG (nmol/L)End of trial 25OHD for IG (nmol/L)OR (95% CI)
Chapuy et al., 2002

Jadad = 3
2583800 D3 + 1,200 mg Ca2275 (graph)0.79
(0.54–1.17)
Chapuy et al., 1992

Jadad = 2
1.53,270800 D3 + 1,200 mg Ca401050.72
(0.58–0.90)
Lips et al., 1996

Jadad = 5
42,578400 D327621.12
(0.86–1.44)
Dawson-Hughes et al., 1997b

Jadad = 4
3389700 D3 + 500 mg Ca82.7 M, 67.5 F1120.42

(0.20–0.88)
Law et al., 2006

Jadad = 2
13,7171,100 D259771.4
(0.9–2.0)
Pfeifer et al., 2000

Jadad = 3
1148800 D3 + 1,200 mg Ca25.666.10.48
(0.12–1.99)
Komulainen et al., 1998

Jadad = 3
5232300 D3 + 500 mg Ca28.637.50.71
(0.31–1.61)
Grant et al., 2005

Jadad = 5
55,292800 D3 with or without 1,000 mg Ca3962.21.02
(0.84–1.22)
Flicker et al., 2005

Jadad = 4
26251,100 D2 + 1,000 mg CaNRNR0.69
(0.4–1.18)
Jackson et al., 2006

Jadad = 4
736,282400 D3 + 1,000 mg Ca46NR0.97
(0.91–1.03)
Porthouse et al., 2005

Jadad = 3
23,314800 D3 + 1,000 mg Ca0.96
(0.65–1.46)
Unequal

1.09
(0.60–1.96)
Equal
Trivedi et al., 2003

Jadad = 3
52,686100,000 D3 4 moNR74.30.78
(0.60–1.00)
Harwood et al., 2004

Jadad = 3
1150800 D3 + 1,000 mg Ca28–3040–500.58
(0.13–2.64)

NOTE: CI = confidence interval; F = female; IG = intervention group; IU = International Units; OR = odds ratio; M = male; mo = month(s); NR = not reported; y = year(s).

a

This table has been truncated for the purposes of this chapter, but it can be found in its entirety in Appendix C.

b

Jadad score is based on a scale of 1 to 5. See Box 4-1 for details on the scoring system.

SOURCE: Modified from Cranney et al. (2007).

From: 4, Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D

Cover of Dietary Reference Intakes for Calcium and Vitamin D
Dietary Reference Intakes for Calcium and Vitamin D.
Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al., editors.
Washington (DC): National Academies Press (US); 2011.
Copyright © 2011, National Academy of Sciences.

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