Table 14TPMT activity in various disease groups

StudyPopulationTPMT activity (U/mL RBCs)
Gisbert 2007104All study participants20.1 ± 6 (Range 0–46.4)
Inflammatory bowel disease (n=7046)20.4 ± 6
Autoimmune hepatitis (n=359)21.5 ± 6
Multiple sclerosis (n=814)18.4 ± 6
Myasthenia gravis (n=344)20.9 ± 6
Pemphigus (n=133)21.1 ± 6
Zhang 2007106Healthy control (n=241)16.03 ± 4.16
Chronic renal failure (n=30): before hemodialysis33.88 ± 12.33
Chronic renal failure (n=30): after hemodialysis17.89 ± 5.24

Abbreviations: n = number in group; RBCs = red blood cells; TPMT = thiopurine methyltransferase; U = Unit = nanomole per hour.

From: 3, Results

Cover of Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs
Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-Based Drugs.
Evidence Reports/Technology Assessments, No. 196.
Booth RA, Ansari MT, Tricco AC, et al.

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