List of Acronyms/Abbreviations

Publication Details

6-MMP

6-methylmercaptopurine

6-MMPR

6-methlyMP ribonucleotide

6-MP

6-mercaptopurine

6-MTG

6-methylthioguanine

6-TG

6-thioguanine

6-tGN

deoxy-6-thioguanosine 5′ triphosphate

6-tIMP

6-thiomercaptopurine

AACC

American Association for Clinical Chemistry

AHRQ

Agency for Health Research Quality

ALL

acute lymphoblastic leukemia

AO

aldehyde oxidase

AST

aspartate aminotransferase

AZA

azathioprine

CI

confidence interval

CK

creatinine kinase

CLSI

Clinical and Laboratory Standards Institute

CV

coefficient of variance

CLIB

Cochrane Library

FN

false negative

FP

false positive

g

gram

GD

guanine deaminase

h

hour

Hb

haemoglobin

HGPRT

hypoxanthine-guanine phosphoribosyl transferase

HPLC

high performance liquid chromatography

HQOL

health related quality of life

HWE

Hardy-Weinberg equilibrium

IBD

inflammatory bowel disease

IC50

concentration of inhibitor at which enzyme activity is 50 percent of uninhibited activity

ICU

intensive care unit

IMPDH

inosine monophosphate dehydrogenase KQ key question

MALDI-TOF

Matrix-assisted laser desorption/ionization, with time-of-flight mass spectrometry

mg

milligram

n

number in group with particular characteristic

N

total number in study or group

nmol

nanomole

OR

odds ratio

p

probability

PCR

polymerase chain reaction

pmol

picomol

QUADAS

Quality Assessment of Diagnostic Accuracy Studies

RBCs

red blood cells

RFLP

restriction fragment length polymorphism

SAE

serious adverse events

SAM

S-adenosyl-L-methionine

SNPs

single nucleotide polymorphisms

TARGET

TPMT: Azathioprine Response to Genotyping and Enzyme Testing study

TN

true negative

TP

true positive

TPMT

thiopurine methyltransferase

U

unit (nmol/h production in an enzymatic reaction)

WDAE

withdrawal due to adverse events

XO

xanthine oxidase