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Smith B, Peterson K, Fu R, et al. Drug Class Review: Drugs for Fibromyalgia: Final Original Report [Internet]. Portland (OR): Oregon Health & Science University; 2011 Apr.

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Drug Class Review: Drugs for Fibromyalgia: Final Original Report [Internet].

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Appendix EExcluded studies

The following full-text publications were considered for inclusion but failed to meet the criteria for this report. Exclusion codes: 2=ineligible outcome, 3=ineligible intervention, 4=ineligible population, 5=ineligible publication type, 6=ineligible study design

Excluded studiesExclusion code
Head-to-head trials
Goldenberg DL, Felson DT, Dinerman H. A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis Rheum. Nov 1986;29(11):1371–1377.6
Kravitz HM, Katz RS, Helmke N, Jeffriess H, Bukovsky J, Fawcett J. Alprazolam and ibuprofen in the treatment of fibromyalgia - Report of a double-blind placebo-controlled study. J Musculoskelet Pain. 1994;2(1):3–27.4
Ozerbil O, Okudan N, Gokbel H, Levendoglu F. Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia. Clin Rheumatol. Jul 2006;25(4):495–497.2
Quijada-Carrera J, Valenzuela-Castano A, Povedano-Gomez J, et al. Comparison of tenoxicam and bromazepan in the treatment of fibromyalgia: a randomized, double- blind, placebo-controlled trial. Pain. May-Jun 1996;65(2–3):221–225.3
Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis Rheum. May 1991;34(5):552–560.4
Sorensen J, Bengtsson A, Ahlner J, Henriksson KG, Ekselius L, Bengtsson M. Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs. J Rheumatol. Aug 1997;24(8):1615–1621.3
Sorensen J, Bengtsson A, Backman E, Henriksson KG, Bengtsson M. Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine. Scand J Rheumatol. 1995;24(6):360–365.3
Ware MA, Fitzcharles M-A, Joseph L, Shir Y. The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Anesth Analg. Feb 2010;110(2):604–610.3
Placebo-controlled trials
Bennett RM, Clark SC, Walczyk J. A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia. Am J Med. Mar 1998;104(3):227–231.3
Bennett RM, Kamin M, Karim R, Rosenthal N. Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. Am J Med. May 2003;114(7):537–545.3
Bennett RM, Schein J, Kosinski MR, Hewitt DJ, Jordan DM, Rosenthal NR. Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen. Arthritis Rheum. Aug 15 2005;53(4):519–527.3
Biasi G, Manca S, Manganelli S, Marcolongo R. Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo. Int J Clin Pharmacol Res. 1998;18(1):13–19.3
Branco JC, Danneskiold-Samsoe B, Cherin P, et al. Effect of milnacipran on pain in fibromyalgia: A european, double-blind, randomized, placebo-controlled trial. Ann Neurol. no: M-4, 2009 2009;66(3, Supplement 13):S4.5
Caruso I, Sarzi Puttini PC, Boccassini L, et al. Double-blind study of dothiepin versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. May-Jun 1987;15(3):154–159.4
Chappell AS, Ossanna MJ, Liu-Seifert H, et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain. Dec 2009;146(3):253–260.4
Cuatrecasas G, Riudavets C, Guell MA, Nadal A. Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. A pilot study. BMC Musculoskeletal Disorders. 2007;8:119.3
Distler O, Eich W, Dokoupilova E, et al. Evaluation of the efficacy and safety of terguride in patients with fibromyalgia syndrome: results of a twelve-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis Rheum. Jan 2010;62(1):291–300.3
Drewes AM, Andreasen A, Jennum P, Nielsen KD. Zopiclone in the treatment of sleep abnormalities in fibromyalgia. Scand J Rheumatol. 1991;20(4):288–293.4
Fossaluzza V, De Vita S. Combined therapy with cyclobenzaprine and ibuprofen in primary fibromyalgia syndrome. Int J Clin Pharmacol Res. 1992;12(2):99–102.4
Gronblad M, Nykanen J, Konttinen Y, Jarvinen E, Helve T. Effect of zopiclone on sleep quality, morning stiffness, widespread tenderness and pain and general discomfort in primary fibromyalgia patients. A double-blind randomized trial. Clin Rheumatol. Jun 1993;12(2):186–191.4
Hannonen P, Malminiemi K, Yli-Kerttula U, Isomeri R, Roponen P. A randomized double-blind placebo controlled study of moclobemide and amitriptyline in fibromyalgia. Scand-J-Rheumatol. 1998;27(3):246.5
Holman AJ, Myers RR. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum. Aug 2005;52(8):2495–2505.6
Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B. Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials. J Rheumatol. Mar 1991;18(3):447–451.4
Moldofsky H, Lue FA, Mously C, Roth-Schechter B, Reynolds WJ. The effect of zolpidem in patients with fibromyalgia: a dose ranging, double blind, placebo controlled, modified crossover study. J Rheumatol. Mar 1996;23(3):529–533.3
Olin R, Klein R, Berg PA. A randomised double-blind 16-week study of ritanserin in fibromyalgia syndrome: clinical outcome and analysis of autoantibodies to serotonin, gangliosides and phospholipids. Clin Rheumatol. 1998;17(2):89–94.3
Pae C-U, Masand PS, Marks DM, et al. History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release. World Journal of Biological Psychiatry. 2009;10(4 Pt 2):435–441.2
Palmer R, Forest Laboratories Inc. A Study Of Milnacipran In Patients With Fibromyalgia: Effects On 24 Hour Ambulatory Blood Pressure Monitoring. 2009;Identifier: NCT00618956.2
Sadreddini S, Molaeefard M, Noshad H, Ardalan M, Asadi A. Efficacy of Raloxifen in treatment of fibromyalgia in menopausal women. European Journal of Internal Medicine. Jul 2008;19(5):350–355.3
Skrabek RQ, Galimova L, Ethans K, Perry D. Nabilone for the treatment of pain in fibromyalgia. Journal of Pain. Feb 2008;9(2):164–173.3
Yavuzer G, Kucukdeveci A, Arasil T, Elhan A. Moclobemid treatment in primary fibromyalgia syndrome. European Journal of Physical Medicine and Rehabilitation. 1998;8(2):35–38.3
Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Medicine. May-Jun 2009;10(4):663–672.3
Younger JW, Zautra AJ, Cummins ET. Effects of naltrexone on pain sensitivity and mood in fibromyalgia: no evidence for endogenous opioid pathophysiology. PLoS ONE [Electronic Resource]. 2009;4(4):e5180.2
Yunus MB, Masi AT, Aldag JC. Short term effects of ibuprofen in primary fibromyalgia syndrome: a double blind, placebo controlled trial.[Erratum appears in J Rheumatol 1989 Jun;16(6):855]. J Rheumatol. Apr 1989;16(4):527–532.4
Copyright © 2011, Oregon Health & Science University.
Bookshelf ID: NBK55561


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