Table 1Included interventions

Generic nameTrade nameApproved for treatment of fibromyalgia
Tricyclic antidepressants
AmitriptylineElavil®a
Generic only
DesipramineNorpramin®b
ImipramineTofranil®, Tofranil-PM®, Impril a
NortriptylineAventyl®, Pamelor®
Serotonin norepinephrine reuptake inhibitors
DesvenlafaxinePristiq®
VenlafaxineEffexor®, Effexor XR®
Selective serotonin reuptake inhibitors
CitalopramCelexa®
EscitalopramLexapro®, Cipralex®c
FluoxetineProzac®, Prozac weeklyb
FluvoxamineLuvox®, Luvox CR®b
ParoxetinePaxil®, Paxil CR®, Pexeva®
SertralineZoloft®
Selective serotonin and norepinephrine reuptake inhibitors
DuloxetineCymbalta®bX
MilnacipranSavella®X
Noradrenergic and specific serotonergic reuptake inhibitor
MirtazapineRemeron®, Remeron Soltab®
Norepinephrine and dopamine reuptake inhibitor
BupropionWellbutrin®b, Wellbutrin SR®, Wellbutrin XL®
Serotonin receptor antagonist
Nefazodone bGeneric only b
Antiepileptic drugs
CarbamazepineTegretol®, Tegretol XR®, Carbatrol®, Equetro®, Mazepine a
Divalproex dDepakote®b, Depakote ER®b, Epival®a
Ethotoin bPeganone®b
GabapentinNeurontin®
LacosamideVimpat®
LamotrigineLamictal®, Lamictal ODT®, Lamictal XR®, Lamictal CD®
LevetiracetamKeppra®, Keppra XR
OxcarbazepineTrileptal®
PhenytoinDilantin®
PregabalinLyrica®X
Tiagabine bGabitril®b
TopiramateTopamax®
Valproic acid dDepakene®, Depacon®b Stavzor®
Zonisamide bZonegran®b
Skeletal muscle relaxants
CyclobenzaprineAmrix®, Flexeril®

Abbreviations: CD, chewable dispersible; CR, controlled-release; ER, extended-release; HP, high potency; ODT, orally disintegrating tablet; PM, pamoate; SR, sustained-release; XL, extended-release; XR, extended-release.

a

Available in Canada, not available in the United States.

b

Available in the United States, not available in Canada.

c

Canadian trade name.

d

Also known as valproate.

From: Methods

Cover of Drug Class Review: Drugs for Fibromyalgia
Drug Class Review: Drugs for Fibromyalgia: Final Original Report [Internet].
Smith B, Peterson K, Fu R, et al.
Portland (OR): Oregon Health & Science University; 2011 Apr.
Copyright © 2011, Oregon Health & Science University.

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