Table 51GRADE evidence summary for pharmacological interventions for aggression

Anticonvulsants versus placebo for aggression
Patient or population: Antisocial personality disorder diagnostic construct – aggression
Intervention: Anticonvulsant
Comparison: Placebo
OutcomesNo. of participants (studies)Quality of the evidence (GRADE)Comments
Aggression (end of treatment)332 (4)⊕○○○
very low1,2,3
SMD −0.13 (−0.35 to 0.09)
Leaving the study early due to adverse events354 (4)⊕○○○
very low1,2,3
RR 3.94 (1.92 to 8.11)
Aggression change score (end of treatment)84 (2)⊕⊕○○
low1,2
SMD −0.13 (−0.56 to 0.3)
SSRI antidepressants versus placebo for aggression
Patient or population: Antisocial personality disorder diagnostic construct – aggression
Intervention: SSRI antidepressant
Comparison: Placebo
OutcomesNo. of participants (studies)Quality of the evidence (GRADE)Effect size
Aggression (end of treatment)40 (1)⊕○○○
very low1,2
SMD −0.73 (−1.41 to −0.04)
Leaving the study early due to adverse events40 (1)⊕⊕○○
low1,2
RR 1.53 (0.06 to 40.09)
Lithium versus placebo for aggression
Patient or population: Antisocial personality disorder diagnostic construct – aggression
Intervention: Lithium
Comparison: Placebo
OutcomesNo. of participants (studies)Quality of the evidence (GRADE)Comments
Aggression (end of treatment)41 (1)⊕⊕○○
low1
SMD −0.6 (−1.23 to 0.03)
Leaving the study early66 (1)⊕⊕○○
low1,2
RR 1.2 (0.64 to 2.24)
1

I squared >50%

2

Population does not include antisocial personality disorder

3

Wide confidence intervals

1

10% of population has antisocial personality disorder

2

Few participants

1

Population does not include antisocial personality disorder

2

Few participants resulting in wide confidence intervals

From: 7, INTERVENTIONS FOR PEOPLE WITH ANTISOCIAL PERSONALITY DISORDER AND ASSOCIATED SYMPTOMS AND BEHAVIOURS

Cover of Antisocial Personality Disorder
Antisocial Personality Disorder: Treatment, Management and Prevention.
NICE Clinical Guidelines, No. 77.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © 2010, The British Psychological Society & The Royal College of Psychiatrists.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the British Psychological Society.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.