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National Toxicology Program. NTP Technical Report on the Toxicity Studies of Cedarwood Oil (Virginia) (CASRN 8000-27-9) Administered Dermally to F344/N Rats and B6C3F1/N Mice: Toxicity Report 86 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2016 Nov.
NTP Technical Report on the Toxicity Studies of Cedarwood Oil (Virginia) (CASRN 8000-27-9) Administered Dermally to F344/N Rats and B6C3F1/N Mice: Toxicity Report 86 [Internet].
Show details- 1.
- The Merck Index. 11th ed. Rahway (NJ): Merck and Company; 1989.
- 2.
- Ciesla W. Non-wood forest products from conifers In: Non-Wood Forest Products, Vol. 12. Rome, Italy: Food and Agriculture Organization of the United Nations (FAO); 1998.
- 3.
- Coppen J. Flavours and fragrances of plant origin In: Non-Wood Forest Products, Vol. 1. Rome, Italy: Food and Agriculture Organization of the United Nations (FAO); 1995.
- 4.
- Dunford NT, Hiziroglu S, Holcomb R. Effect of age on the distribution of oil in Eastern redcedar tree segments. Bioresour Technol. 2007;98(14):2636–2640. http://dx
.doi.org/10 .1016/j.biortech.2006.09.058 [PubMed: 17141500] - 5.
- Franz H, Frank R, Rytter M, Haustein UF. Allergic contact dermatitis due to cedarwood oil after dermatoscopy. Contact Dermat. 1998;38(3):182–183. http://dx
.doi.org/10 .1111/j.1600-0536.1998.tb05701.x [PubMed: 9536426] - 6.
- Gerhartz W. Ullmann’s encyclopedia of industrial chemistry. Deerfield Beach (FL): VCH Publishers; 1985. p. 220.
- 7.
- Merory J. Food flavorings: Composition, manufacture, and use. 2nd ed. Westport (CT): AVI Publishing Company, Inc; 1968.
- 8.
- United States Environmental Protection Agency (USEPA). Reregistration Eligibility Decision (RED): Cedarwood oil. Washington, DC: US Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances; 1993. EPA-723-S-93-012. https://web
.archive.org /web/20080619000737/https://www .epa.gov /oppsrrd1/REDs/old_reds/cedarwood_oil .pdf - 9.
- International Organization for Standardization (ISO). Essential Oils. Oil of cedarwood, Virginian (Juniperus virginiana L) ISO 4724:2004€. 2004.
- 10.
- Hazardous Substance Data Bank (HSDB). Cedarwood oil. TOXNET: Toxicology Data Network, National Library of Medicine; 2014. https://toxnet
.nlm.nih.gov/hsdb.htm [Accessed: July 2014] - 11.
- Research Institute for Fragrance Materials (RIFM)Fragrance raw materials monographs: cedarwood oil Virginia. Food Cosmet Toxicol. 1974;12:845–846. http://dx
.doi.org/10 .1016/0015-6264(74)90147-3 - 12.
- Food and Drug Administration (FDA). Modification in voluntary filing of cosmetic product ingredient and cosmetic raw material composition statements. Federal Register Vol 57, No 18. Washington, DC; 1992. p. 3128-3130.
- 13.
- Cosmetic Ingredient Review (CIR)Final report on the safety assessment of Juniperus communis Extract, Juniperus oxycedrus Extract, Juniperus oxycedrus Tar, Juniperus phoenicea extract, and Juniperus virginiana Extract. Int J Toxicol. 2001;20 Suppl 2:41–56. http://dx
.doi.org/10 .1080/10915810160233758 [PubMed: 11558640] - 14.
- Craig AM, Karchesy JJ, Blythe LL, del Pilar González-Hernández M, Swan LR. Toxicity studies on western juniper oil (Juniperus occidentalis) and Port-Orford-cedar oil (Chamaecyparis lawsoniana) extracts utilizing local lymph node and acute dermal irritation assays. Toxicol Lett. 2004;154(3):217–224. http://dx
.doi.org/10 .1016/j.toxlet.2004.08.004 [PubMed: 15501613] - 15.
- United States Environmental Protection Agency (USEPA). Wood oils and gums summary document. Washington, DC: US Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances; 2009. Docket No. EPA-HQ-OPP-2009-0258. https://archive
.epa.gov /oppsrrd1/registration_review /web/html/index-291.html - 16.
- Barnard DR. Repellency of essential oils to mosquitoes (Diptera: culicidae). J Med Entomol. 1999;36(5):625–629. http://dx
.doi.org/10 .1093/jmedent/36.5.625 [PubMed: 10534958] - 17.
- Curtis CF, Lines JD, Ijumba J, Callaghan A, Hill N, Karimzad MA. The relative efficacy of repellents against mosquito vectors of disease. Med Vet Entomol. 1987;1(2):109–119. http://dx
.doi.org/10 .1111/j.1365-2915.1987.tb00331.x [PubMed: 2908762] - 18.
- Singh D, Rao SM, Tripathi AK. Cedarwood oil as a potential insecticidal agent against mosquitoes. Naturwissenschaften. 1984;71(5):265–266. http://dx
.doi.org/10.1007/BF00441340 [PubMed: 6146933] - 19.
- Eller FJ, Vander Meer RK, Behle RW, Flor-Weiler LB, Palmquist DE. Bioactivity of cedarwood oil and cedrol against arthropod pests. Environ Entomol. 2014;43(3):762–766. http://dx
.doi.org/10.1603/EN13270 [PubMed: 24690252] - 20.
- Takao Y, Kuriyama I, Yamada T, Mizoguchi H, Yoshida H, Mizushina Y. Antifungal properties of Japanese cedar essential oil from waste wood chips made from used sake barrels. Mol Med Rep. 2012;5(5):1163–1168. [PubMed: 22395293]
- 21.
- Acevedo Z. Abortion in early America. Women Health. 1979;4(2):159–167. http://dx
.doi.org/10.1300/J013v04n02_05 [PubMed: 10297561] - 22.
- Gosselin R, Smith R, Hodge H. Clinical toxicology of commercial products. 5th ed. Baltimore (MD): Williams and Wilkins; 1984.
- 23.
- Welch KD, Cook D, Gardner DR, Parsons C, Pfister JA, Panter KE. A comparison of the abortifacient risk of western juniper trees in Oregon. Rangelands. 2013;35(1):40–44. http://dx
.doi.org/10 .2111/RANGELANDS-D-12-00056.1 - 24.
- National Institute for Occupational Safety and Health (NIOSH). National Occupational Exposure Survey (1981-1983) [unpublished provisional data]. Cincinnati, OH. 1990.
- 25.
- Code of Federal Regulations (CFR). 21:§172.515.
- 26.
- Code of Federal Regulations (CFR). 40:§152.125.
- 27.
- United States Environmental Protection Agency (USEPA). Cedarwood oil; Substance Registry Services (SRS) entry. 2013. https://ofmpub
.epa.gov /sor_internet/registry /substreg/searchandretrieve /substancesearch/search .do?details =displayDetails&selectedSubstanceId=16188 - 28.
- Hong JY, Lee BH, Kim TH, Hong J, Lee KM, Yoo SD, Lee HS. GC-MS/MS method for the quantification of α-cedrene in rat plasma and its pharmacokinetic application. J Sep Sci. 2013;36(21-22):3558–3562. http://dx
.doi.org/10.1002/jssc.201300828 [PubMed: 23996797] - 29.
- Kim TH, Yoo SD, Lee HS, Lee KM, Seok SH, Kim MG, Jung BH, Kim MG, Shin BS. In vivo absorption and disposition of α-cedrene, a sesquiterpene constituent of cedarwood oil, in female and male rats. Drug Metab Pharmacokinet. 2015;30(2):168–173. http://dx
.doi.org/10 .1016/j.dmpk.2014.12.003 [PubMed: 25857232] - 30.
- Frosch PJ, Pilz B, Andersen KE, Burrows D, Camarasa JG, Dooms-Goossens A, Ducombs G, Fuchs T, Hannuksela M, Lachapelle JM, et al. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermat. 1995;33(5):333–342. http://dx
.doi.org/10 .1111/j.1600-0536.1995.tb02048.x [PubMed: 8565489] - 31.
- Abifadel R, Mortureux P, Perromat M, Ducombs G, Taieb A. Contact sensitivity to flavourings and perfumes in atopic dermatitis. Contact Dermat. 1992;27(1):43–46. http://dx
.doi.org/10 .1111/j.1600-0536.1992.tb05196.x [PubMed: 1424590] - 32.
- Fujii T, Furukawa S, Suzuki S. Studies on compounded perfumes for toilet goods: on the non-irritative compounded perfumes for soaps [in Japanese, English abstract]. Journal of Japan Oil Chemists’ Society. 1972;21:904–908. https://doi
.org/10.5650/jos1956.21.904 - 33.
- Kligman AM. The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol. 1966;47(5):393–409. http://dx
.doi.org/10.1038/jid.1966.160 [PubMed: 5924294] - 34.
- Belsito D, Bickers D, Bruze M, Calow P, Dagli ML, Fryer AD, Greim H, Miyachi Y, Saurat JH, Sipes IG., RIFM Expert Panel. A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. Food Chem Toxicol. 2013;62 Suppl 1:S1–S44. http://dx
.doi.org/10 .1016/j.fct.2013.09.033 [PubMed: 24246175] - 35.
- Lapczynski A, Isola DA, Christian MS, Diener RM, Api AM. Evaluation of the developmental toxicity of acetyl cedrene. Int J Toxicol. 2006;25(5):423–428. http://dx
.doi.org/10 .1080/10915810600870575 [PubMed: 16940015] - 36.
- Ogata A, Ando H, Kubo Y, Nagasawa A, Ogawa H, Yasuda K, Aoki N. Teratogenicity of thujaplicin in ICR mice. Food Chem Toxicol. 1999;37(11):1097–1104. http://dx
.doi.org/10 .1016/S0278-6915(99)00097-6 [PubMed: 10566881] - 37.
- Adams R. Cedar wood oil analyses and properties. In: Linsken H, Jackson J, editors. Modern Methods of Plant Analysis New Series: Essential Oils and Waxes. Vol. 12. New York (NY): Springer-Verlag; 1991. p. 159–173. http://dx
.doi.org/10 .1007/978-3-642-84023-4_8 - 38.
- Adams R. Identification of essential oils by ion trap mass spectrometry. San Diego (CA): Academic Press, Inc.; 1989.
- 39.
- Adams R. Identification of essential oil components by gas chromatography/quadrupole mass spectroscopy. Carol Stream (IL): Allured Publishing Corporation; 2001.
- 40.
- Maronpot RR, Boorman GA. Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicol Pathol. 1982;10(2):71–78. http://dx
.doi.org/10 .1177/019262338201000210 [PubMed: 28094716] - 41.
- Boorman GA, Montgomery CA Jr, Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF. Quality assurance in pathology for rodent carcinogenicity studies. In: Milman HA, Weisburger EK, editors. Handbook of Carcinogen Testing. Park Ridge (NJ): Noyes Publications; 1985. p. 345–357.
- 42.
- Gart JJ, Chu KC, Tarone RE. Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J Natl Cancer Inst. 1979;62(4):957–974. [PubMed: 285297]
- 43.
- Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 1955;50(272):1096–1121. http://dx
.doi.org/10 .1080/01621459.1955.10501294 - 44.
- Williams DA. A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics. 1971;27(1):103–117. http://dx
.doi.org/10.2307/2528930 [PubMed: 5547548] - 45.
- Williams DA. The comparison of several dose levels with a zero dose control. Biometrics. 1972;28(2):519–531. http://dx
.doi.org/10.2307/2556164 [PubMed: 5037867] - 46.
- Shirley E. A non-parametric equivalent of Williams’ test for contrasting increasing dose levels of a treatment. Biometrics. 1977;33(2):386–389. http://dx
.doi.org/10.2307/2529789 [PubMed: 884197] - 47.
- Williams DA. A note on Shirley’s nonparametric test for comparing several dose levels with a zero-dose control. Biometrics. 1986;42(1):183–186. http://dx
.doi.org/10.2307/2531254 [PubMed: 3719054] - 48.
- Dunn OJ. Multiple comparisons using rank sums. Technometrics. 1964;6(3):241–252. http://dx
.doi.org/10 .1080/00401706.1964.10490181 - 49.
- Jonckheere A. A distribution-free k-sample test against ordered alternatives. Biometrika. 1954;41:133–145. http://dx
.doi.org/10 .1093/biomet/41.1-2.133 - 50.
- Dixon W, Massey F. Introduction to statistical analysis. 2nd ed. New York (NY): McGraw Hill Book Company Inc; 1957. http://dx
.doi.org/10.2307/2332898 - 51.
- Girard DM, Sager DB. The use of Markov chains to detect subtle variation in reproductive cycling. Biometrics. 1987;43(1):225–234. http://dx
.doi.org/10.2307/2531963 [PubMed: 3567307] - 52.
- Wilcoxon F. Individual comparisons by ranking methods. Biometrics Bull. 1945; 1(6):80-83. http://dx
.doi.org/10.2307/3001968 [PubMed: 18903631] - 53.
- Code of Federal Regulations (CFR). 21:Part 58.
- 54.
- Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2–141. http://dx
.doi.org/10.1002/em.2850190603 [PubMed: 1541260] - 55.
- MacGregor JT, Wehr CM, Henika PR, Shelby MD. The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fundam Appl Toxicol. 1990;14(3):513–522. http://dx
.doi.org/10 .1016/0272-0590(90)90255-I [PubMed: 2111256] - 56.
- Roe FJ, Field WE. Chronic toxicity of essential oils and certain other products of natural origin. Food Cosmet Toxicol. 1965;3(2):311–323. http://dx
.doi.org/10 .1016/S0015-6264(65)80090-6 [PubMed: 5859246] - 57.
- Swenberg JA. Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment. Environ Health Perspect. 1993;101 Suppl 6:39–44. http://dx
.doi.org/10.1289/ehp.93101s639 [PMC free article: PMC1520017] [PubMed: 7517351] - 58.
- Doi AM, Hill G, Seely J, Hailey JR, Kissling G, Bucher JR. α 2u-globulin nephropathy and renal tumors in national toxicology program studies. Toxicol Pathol. 2007;35(4):533–540. http://dx
.doi.org/10 .1080/01926230701338941 [PMC free article: PMC2104517] [PubMed: 17562486] - 59.
- United States Environmental Protection Agency (USEPA). Alpha 2u-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat. Washington, DC: U.S. Environmental Protection Agency, prepared for the Risk Assessment Forum; 1991. EPA/625/3-91/019F.
- 60.
- Intermational Agency for Research on Cancer (IARC). Species differences in thyroid, kidney and urinary bladder carcinogenesis: IARC Scientific Publications No. 147. Lyon, France: Intermational Agency for Research on Cancer (IARC); 1999.
- 61.
- Amacher DE, Schomaker SJ, Burkhardt JE. The relationship among microsomal enzyme induction, liver weight and histological change in rat toxicology studies. Food Chem Toxicol. 1998;36(9-10):831–839. http://dx
.doi.org/10 .1016/S0278-6915(98)00066-0 [PubMed: 9737431] - 62.
- Hashimoto M, Davis DC, Gillette JR. Effect of different routes of administration of cedrene on hepatic drug metabolism. Biochem Pharmacol. 1972;21(10):1514–1517. http://dx
.doi.org/10 .1016/0006-2952(72)90377-2 [PubMed: 5029428] - 63.
- Sabine JR. Exposure to an environment containing the aromatic red cedar, Juniperus virginiana: procarcinogenic, enzyme-inducing and insecticidal effects. Toxicology. 1975;5(2):221–235. http://dx
.doi.org/10 .1016/0300-483X(75)90119-5 [PubMed: 174251] - 64.
- Jeong H-U, Kwon S-S, Kong TY, Kim JH, Lee HS. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522–1532. http://dx
.doi.org/10 .1080/15287394.2014.955906 [PubMed: 25343299] - 65.
- Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352(10):1011–1023. http://dx
.doi.org/10.1056/NEJMra041809 [PubMed: 15758012] - 66.
- Everds NE, Snyder PW, Bailey KL, Bolon B, Creasy DM, Foley GL, Rosol TJ, Sellers T. Interpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment. Toxicol Pathol. 2013;41(4):560–614. http://dx
.doi.org/10 .1177/0192623312466452 [PubMed: 23475558] - 67.
- Bellanato J, Hidalgo A. Infrared analysis of essential oils. London, UK: Heyden and Son Limited; 1971.
- 68.
- Sigma-Aldrich Chemical Company. The Aldrich library of infrared spectra: Vol 3, spectrum 66B. Milwaukee, WI: Sigma-Aldrich Chemical Company; 1981.
- References - NTP Technical Report on the Toxicity Studies of Cedarwood Oil (Virg...References - NTP Technical Report on the Toxicity Studies of Cedarwood Oil (Virginia) (CASRN 8000-27-9) Administered Dermally to F344/N Rats and B6C3F1/N Mice
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