From: 2, Evidence review and recommendations
Copyright © National Institute for Health and Care Excellence, 2015.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Prophylaxis against infective endocarditis. London: National Institute for Health and Care Excellence (NICE); 2015 Sep. (NICE Guideline Addendum, No. 64.1.)
Table 12Explanation of fields used in the economic evidence profile
| Item | Description |
|---|---|
| Study | This field is used to reference the study and provide basic details on the included interventions and country of origin. |
| Applicability | Applicability refers to the relevance of the study to specific review questions and the NICE reference case. Attributes considered include population, interventions, healthcare system, perspective, health effects and discounting. The applicability of the study is rated as:
|
| Limitations | This field provides an assessment of the methodological quality of the study. Attributes assessed include the relevance of the model’s structure to the review question, timeframe, outcomes, costs, parameter sources, incremental analysis, uncertainty analysis and conflicts of interest. The methodological quality of the evaluation is rated as having:
|
| Other comments | This field contains particular issues that should be considered when interpreting the study, such as model structure and timeframe. |
| Incremental cost | The difference between the mean cost associated with one strategy and the mean cost of a comparator strategy. |
| Incremental effect | The difference between the mean health effect associated with the intervention and the mean health effect associated with the comparator. This is usually represented by quality-adjusted life years (QALYs) in accordance with the NICE reference case. |
| Incremental cost effectiveness ratio (ICER) | The incremental cost divided by the incremental effect which results in the cost per quality-adjusted life year gained (or lost). Negative ICERs are not reported as they could represent very different conclusions: either a decrease in cost with an increase in health effects; or an increase in cost with a decrease in health effects. For this reason, the word ‘dominates’ is used to represent an intervention that is associated with decreased costs and increased health effects compared to the comparator, and the word ‘dominated’ is used to represent an intervention that is associated with an increase in costs and decreased health effects. |
| Uncertainty | A summary of the extent of uncertainty about the ICER. This can include the results of deterministic or probabilistic sensitivity analysis or stochastic analyses or trial data. |
- Table 12, Explanation of fields used in the economic evidence profile - Prophyla...Table 12, Explanation of fields used in the economic evidence profile - Prophylaxis against infective endocarditis
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