Disease Modifying Agents
Generic Name
Brand Name		Type of AgentApproval for MSIndication
Type of MS		Route and
Regimen		Likelihood Score
Alemtuzumab
Campath		mAb to
CD-52		2001RRMS,
SPMS		iv [3 or 5 days]
every 12 months		D
Cladribine
Mavenclad		Purine Antimetabolite2017RRMS,
SPMS		oral daily in two
4- to 5-day courses		E
Daclizumab
Zinbryta		mAb to
IL2 Receptor		2017
Withdrawn		RRMSsc once monthlyC
Dimethyl Fumarate
Tecfidera		Nrf2
Activator		2013RRMS,
SPMS, CIS		oral twice dailyC
Diroximel Fumarate
Vumerity*		Nrf2
Activator		2019RRMS,
SPMS, CIS		oral twice dailyE*
Monomethyl Fumarate
Bafiertam*		Nrf2
Activator		2020RRMS,
SPMS, CIS		oral twice dailyE*
Fingolimod
Gelenya		S1P Receptor Modulator2010RRMS,
SPMS, CIS		oral once dailyC
Glatiramer Acetate
Glatopa		Amino Acid Polymers1996RRMS,
SPMS, CIS		sc daily or thrice weeklyB
Interferon beta-1a
Avonex, Rebif		Recombinant
Cytokine		1996RRMS,
SPMS, CIS		im weekly
sc thrice weekly		A
Interferon beta-1b
Betaseron, Extavia		Recombinant
Cytokine		1993RRMS,
SPMS, CIS		sc every other dayA
Peginterferon beta-1a
Plegridy		Pegylated
Rec Cytokine		2014RRMS,
SPMS, CIS		sc every 2 weeksA
Mitoxantrone
Generic		Cytotoxic Antibiotic2006RRMS,
SPMS		iv every 3 monthsD
Natalizumab
Tysabri		mAb to α4β1 integrin2005RRMS, CIS, SPMSiv every 4 weeksC
Ocrelizumab
Ocrevus		mAb to
CD-20		2017RRMS, CIS, SPMS, PPMSiv every 6 monthsD
Ozanimod
Zeposia		S1P Receptor Modulator2020RRMS, CIS, SPMSoral dailyE*
Ponesimod
Ponvory		S1P Receptor Modulator2021RRMS, CIS, SPMSoral dailyE*
Siponimod
Mayzent		S1P Receptor Modulator2019RRMS, CIS,
SPMS		oral dailyE*
Teriflunomide
Aubagio		Pyrimidine Syn Inhibitor2012RRMS, CIS,
SPMS		oral dailyD
Symptomatic Therapy
Generic Name
Brand Name		Type of AgentApprovalIndicationRoute and
Regimen		Likelihood Score
Dalfampridine
Ampyra		Pyrimidine Analogue2010RRMSoral twice dailyE*

From: Multiple Sclerosis Agents

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