Table 1Example evidence profile table

Quality assessmentSummary of findings
No. of patientsEffect
No. of studiesQuality of included studiesConsistencyDirectnessOther modifying factorsCBTWaitlistEffect sizeLikelihood of clinically important effectOverall qualityImportance
Carbamazepine versus placebo
Efficacy
Mania: change score at endpoint (manic only)
Weisler 2004
Weisler 2005
Sign: 1+ (−1)NoneAcute maniaStrong effect (+1)134146WMD = −6.87 (−9.24, −4.49)Very likely (favouring carbamazepine)ModerateCritical
Acceptability/tolerability
Leaving treatment early for any reason
Weisler 2004
Weisler 2005
Sign: 1+ (−1)Significant heterogeneity (−1): random effects model usedAcute maniaNone134146RR (random effects) = 0.79 (0.59, 1.06)Likely (favouring carbamazepine)LowCritical

From: 3, METHODS USED TO DEVELOP THIS GUIDELINE

Cover of Antenatal and Postnatal Mental Health
Antenatal and Postnatal Mental Health: The NICE Guideline on Clinical Management and Service Guidance.
NICE Clinical Guidelines, No. 45.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2007.
Copyright © 2007, The British Psychological Society & The Royal College of Psychiatrists.

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