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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Naloxegol

Last Revision: April 15, 2026.

Estimated reading time: 1 minute

CASRN: 854601-70-0

image 162108769 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the excretion of naloxegol into breastmilk. Because of the possibility of inducing opioid withdrawal in the breastfed infant, the manufacturer states that breastfeeding is not recommended during treatment with naloxegol. If it is used, observe breastfed infants who have been exposed to opioids during pregnancy or postpartum for signs of opioid withdrawal, especially diarrhea. An alternate drug may be preferable.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Methylnaltrexone, Naldemedine

Substance Identification

Substance Name

Naloxegol

CAS Registry Number

854601-70-0

Drug Class

Breast Feeding

Lactation

Milk, Human

Gastrointestinal Agents

Narcotic Antagonists

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK543160PMID: 31260226