Table 55Changes in lipid parameters (mean change from baseline, mg/dL) (continued)

Scott, 200730Goldstein, 200731aWilliams-Herman, 200932Williams-Herman, 201033b
S100PBOGlipS100M1M2S/M1S/M2PBOS100M1M2S/M1S/M2S100M1M2S/M1S/M2
Total cholesterol4.31.50.77NRNRNRNRNRNR+0.50−0.2−6.6−8.8+1.4−6.1−0.6−6.8−4.7
HDL1.500.79+0.5+1.4+2.3+1.2+1.8+1.3+0.1+2.4+3.1+1.7+2.7+2.8+3.4+3.5+1.8+3.1
LDL2.7−1.15−0.77+1.6−3.2−3.6−3.7−5.4+4.8−1.6−3.0−4.8−5.0−8.5+5.6−5.9−3.8−8.4−7.1
TG015.92.65+7−0.2+9.2−13.4−20.5+0.3+15a+6.0a+24.0a−8.0a−15a+3.0− 11.0+18+5.5+1.5

Abbreviations: HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; M1, metformin 1000 mg/d; M2, metformin 2000 mg/d; TG, triglycerides.

a

Reported as median change from baseline.

b

Data received from manufacturer.

From: Results

Cover of Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations
Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet].
Jonas D, Van Scoyoc E, Gerrald K, et al.
Portland (OR): Oregon Health & Science University; 2011 Feb.
Copyright © 2011, Oregon Health & Science University.

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