Table F- 17Exenatide compared with insulin

Domains pertaining to strength of evidenceMagnitude of effectStrength of evidence
Number of Studies; # of SubjectsRisk of Bias (Design/Quality)ConsistencyDirectnessPrecisionSummary Effect Size (95% Confidence Interval)High, Moderate, Low, Insufficient
HbA1c
4;
1245
Medium
4 RCTs/Fair
ConsistentIndirectPreciseNo difference between groups for reductionModerate
Weight
4;
1245
Medium
4 RCTs Fair
ConsistentIndirectImpreciseGreater weight loss with exenatide (treatment difference range 4.1 kg to 5.4 kg)Moderate
Hypoglycemia
4;
1245
Medium
4 RCTs/Fair
ConsistentDirectImpreciseSimilar rates of hypoglycemia between exenatide and insulinModerate

From: Appendix F, Strength of evidence

Cover of Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations
Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet].
Jonas D, Van Scoyoc E, Gerrald K, et al.
Portland (OR): Oregon Health & Science University; 2011 Feb.
Copyright © 2011, Oregon Health & Science University.

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