FIGURE 15. CCK stimulates pancreatic enzyme secretion by both neural and hormonal pathways.


CCK stimulates pancreatic enzyme secretion by both neural and hormonal pathways. This cartoon shows the several pathways mediating meal-stimulated pancreatic secretion that involve CCK. First, meal nutrients, such as fatty acids, amino acids and peptides, delivered from the duodenum stimulate the release of CCK from the CCK-containing I cell to the area around the basolateral surface of the I cell. The CCK released can activate vagal afferent neurons that carry the signal to the dorsal vagal complex where the sensory information is integrated and vagal efferents are activated. Vagal efferents synapse with neurons in the pancreatic ganglia. In turn, via the neurotransmitters, acetylcholine (Ach), gastrin-releasing peptide (GRP) and vasoactive intestinal polypeptide (VIP) effector neurons in the pancreatic ganglia activate secretion by pancreatic acinar cells. In addition to activating the neural pathway, CCK released by the I cell enters the general circulation and may act as a hormone on the pancreatic acinar cells to cause secretion. Adapted from Gorelick F, Pandol, SJ, Topazian M. Pancreatic physiology, pathophysiology, acute and chronic pancreatitis. Gastrointestinal Teaching Project, American Gastroenterologic Association. 2003.

From: Regulation of Whole-Organ Pancreatic Secretion

Cover of The Exocrine Pancreas
The Exocrine Pancreas.
Pandol SJ.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2011 by Morgan & Claypool Life Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.