FIGURE 20. The endothelial cell cytoskeleton.


The endothelial cell cytoskeleton. Polymeric components of the cytoskeleton: actin microfilaments, microtubules and vimentin intermediate filaments, stabilize endothelial cell structure. Cell peripheral (cortical) actin filaments stabilize intercellular junctions and maintain focal adhesion integrity to support normal physiological endothelial barrier function. Microtubules and intermediate filaments provide additional support. Under inflammatory conditions, including RhoA activation, microtubules disassemble into α- and β- tubulin subunits, and actin filaments, reorganize into parallel and linear stress fiber bundles that span the cell interior, pathological characteristics of endothelial hyperpermeability.

From: Chapter 4, The Endothelial Barrier

Cover of Regulation of Endothelial Barrier Function
Regulation of Endothelial Barrier Function.
Yuan SY, Rigor RR.
San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Copyright © 2011 by Morgan & Claypool Life Sciences.

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