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Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

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Drugs and Lactation Database (LactMed) [Internet].

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Last Revision: November 16, 2020.

Estimated reading time: 1 minute

CASRN: 843663-66-1

image 135262331 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Minimal information is available on the clinical use of bedaquiline during breastfeeding. Because bedaquiline is more than 99.9% bound to plasma proteins, exposure of the breastfed infant is likely to be low. However, the half-lives of the drug and its main metabolite are over 5 months. If bedaquiline is required by the mother, it is not a reason to discontinue breastfeeding. Monitor breastfed infants for adverse reactions, such as liver toxicity, nausea, arthralgia, headache, haemoptysis, and chest pain.[1]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A woman who was co-infected with HIV and rifampin-resistant tuberculosis took bedaquiline (dosage not stated) as part of her antituberculosis regimen, which consisted of pyrazinamide and other unnamed drugs. At the 1-month follow-up, the infant was small and not gaining weight well, but the mother was nauseated from her medication regimen and had also lost weight. Six months later after completion of the mother’s therapy, her infant’s weight was increasing, following the normal trajectory of the growth chart, and reaching her developmental milestones.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Loveday M, Hlangu S, Furin J. Breastfeeding in women living with tuberculosis. Int J Tuberc Lung Dis. 2020;24:880–91. [PubMed: 33156754]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Anti-infective Agents

Antitubercular Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.


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