NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
CASRN: 843663-66-1
Drug Levels and Effects
Summary of Use during Lactation
Minimal information is available on the clinical use of bedaquiline during breastfeeding. Because bedaquiline is more than 99.9% bound to plasma proteins, exposure of the breastfed infant is likely to be low. However, the half-lives of the drug and its main metabolite are over 5 months. If bedaquiline is required by the mother, it is not a reason to discontinue breastfeeding. Monitor breastfed infants for adverse reactions, such as liver toxicity, nausea, arthralgia, headache, haemoptysis, and chest pain.[1]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
A woman who was co-infected with HIV and rifampin-resistant tuberculosis took bedaquiline (dosage not stated) as part of her antituberculosis regimen, which consisted of pyrazinamide and other unnamed drugs. At the 1-month follow-up, the infant was small and not gaining weight well, but the mother was nauseated from her medication regimen and had also lost weight. Six months later after completion of the mother’s therapy, her infant’s weight was increasing, following the normal trajectory of the growth chart, and reaching her developmental milestones.[1]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Loveday M, Hlangu S, Furin J. Breastfeeding in women living with tuberculosis. Int J Tuberc Lung Dis. 2020;24:880–91. [PubMed: 33156754]
Substance Identification
Substance Name
Bedaquiline
CAS Registry Number
843663-66-1
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- LactMed App
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Brivaracetam[Drugs and Lactation Database (...]Review Brivaracetam. Drugs and Lactation Database (LactMed). 2006
- Review Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis.[Indian J Microbiol. 2017]Review Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis.Singh P, Kumari R, Lal R. Indian J Microbiol. 2017 Dec; 57(4):371-377. Epub 2017 Oct 24.
- Review Ezogabine[Drugs and Lactation Database (...]Review Ezogabine. Drugs and Lactation Database (LactMed). 2006
- Review Levetiracetam[Drugs and Lactation Database (...]Review Levetiracetam. Drugs and Lactation Database (LactMed). 2006
- Review Vandetanib[Drugs and Lactation Database (...]Review Vandetanib. Drugs and Lactation Database (LactMed). 2006
- Bedaquiline - Drugs and Lactation Database (LactMed)Bedaquiline - Drugs and Lactation Database (LactMed)
Your browsing activity is empty.
Activity recording is turned off.
See more...