TABLE 2-1Three Tiers of Voluntary Children’s Chemical Evaluation Program

Tier 1Tier 2Tier 3
Acute toxicitySubchronic toxicityNeurotoxicity screening battery
Repeated dose toxicity with reproductive and developmental toxicity screensPrenatal developmental toxicity

Reproductive and fertility effects
Carcinogenicity

Developmental neurotoxicity
Bacterial reverse mutation assayImmunotoxicity
In vitro or in vivo chromosomal aberrations or in vivo micronucleus testIn vivo chromosomal aberrations or in vivo micronucleus test

Metabolism and pharmacokinetics

SOURCE: EPA, 2004c.

From: 2, Moving Beyond Compliance: Can Industry Get Ahead of the Curve?

Cover of Global Environmental Health in the 21st Century
Global Environmental Health in the 21st Century: From Governmental Regulation to Corporate Social Responsibility: Workshop Summary.
Institute of Medicine (US), Roundtable on Environmental Health Sciences, Research, and Medicine.
Washington (DC): National Academies Press (US); 2007.
Copyright © 2007, National Academy of Sciences.

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