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Show detailsContinuing Education Activity
Atenolol is a second-generation β-1–selective adrenergic antagonist that helps lower the heart rate and blood pressure of patients while also decreasing myocardial contractility. Atenolol is approved by the U.S. Food and Drug Administration (FDA) for treating hypertension, angina pectoris, and acute myocardial infarction. Off-label uses of atenolol include the treatment of arrhythmias, migraine prophylaxis, paroxysmal supraventricular tachycardia, alcohol withdrawal, thyrotoxicosis, and prophylaxis against secondary myocardial infarction. Atenolol is an alternative to propranolol in the management of infantile hemangiomas. The mechanistic actions of atenolol are complemented by several cardiovascular drugs when managing cardiac emergencies.
This activity provides a comprehensive overview of atenolol, covering its indications, mechanism of action, safe administration, adverse effects, contraindications, monitoring, and toxicity. This activity also highlights the role of an interprofessional team in treating medical conditions using atenolol. Patient outcomes are optimized when this medication is utilized by a team of primary care, emergency medicine, and consulting specialists.
Objectives:
- Identify the FDA-approved indications and off-label uses for atenolol, including hypertension, angina, and acute myocardial infarction.
- Screen patients for asthma, bronchospasm, or obstructive airway diseases to assess the use of atenolol or consider alternative therapies.
- Assess patients for adverse drug reactions and recognize potential complications, such as masked symptoms of hypoglycemia and thyrotoxicosis.
- Collaborate within the interprofessional healthcare team to coordinate comprehensive care for patients using atenolol, ensuring regular renal function, heart rate, and blood pressure monitoring.
Indications
Atenolol is a second-generation β-1–selective adrenergic antagonist that helps lower the heart rate and blood pressure of patients while also decreasing myocardial contractility.
FDA-Approved Indications
Atenolol is approved by the U.S. Food and Drug Administration (FDA) for treating hypertension, angina pectoris, and acute myocardial infarction.
Off-Label Uses
Off-label uses of atenolol include the treatment of arrhythmias, migraine prophylaxis, paroxysmal supraventricular tachycardia, alcohol withdrawal, thyrotoxicosis, and prophylaxis against secondary myocardial infarction.[1][2] Atenolol is an alternative to propranolol in the management of infantile hemangiomas.[3] The American Academy of Neurology (AAN) recommends atenolol as a treatment for episodic migraine.[4] As per the guidelines from the American Society of Clinical Oncology, immune checkpoint inhibitors have the potential to induce thyrotoxicosis. The recommended management approach includes symptomatic control with atenolol/propranolol, along with recommended treatments such as steroids, saturated solution of potassium iodide, and methimazole.[5]
Mechanism of Action
Atenolol, a cardioselective β-1 adrenergic antagonist, selectively binds to the β-1 adrenergic receptors in vascular smooth muscle and the heart. This selective binding blocks the positive inotropic and chronotropic actions initiated by endogenous catecholamines such as isoproterenol, norepinephrine, and epinephrine. As a result, sympathetic stimulation is inhibited.[6] This activity results in a decrease in heart rate, blood pressure, and myocardial contractility. However, atenolol can increase end-diastolic pressure and left ventricular fiber lengths in patients with heart failure, resulting in increased oxygen demand.
In addition, atenolol exerts effects in higher doses by competitively blocking β-2 adrenoreceptors in the bronchial and vascular musculature. The drug lacks membrane-stabilizing or intrinsic sympathomimetic activity. Due to the low lipid solubility, atenolol demonstrates reduced brain penetrance, which results in fewer adverse effects on the central nervous system.[7] As beta-adrenergic receptor antagonists also increase the refractory period of the atrioventricular (AV node), they may also be used off-label to treat supraventricular tachycardia and prevent paroxysmal attacks of atrial fibrillation.[8] The duration of action for atenolol is dose-dependent. After administering a dose, the effects are evident within 1 hour and peak at 2 to 4 hours, persisting for a minimum of 24 hours.[9]
Pharmacokinetics
Absorption: The bioavailability of orally administered atenolol is approximately 50%. Peak blood levels are attained between 2 and 4 hours after oral administration and within 5 minutes after intravenous (IV) administration.
Distribution: As previously mentioned, atenolol, a hydrophilic β-blocker with low lipid solubility, exhibits limited diffusion across the intestinal membrane and blood-brain barrier. The plasma protein binding of the drug is approximately 10%.[10]
Metabolism: Atenolol undergoes minimal hepatic metabolism, with the parent drug being the predominant radiolabeled component in the blood.[11]
Elimination: Atenolol is primarily excreted through the renal route, involving glomerular filtration and active secretion. The elimination half-life is approximately 6 to 7 hours.[12] Organic cation transporters play an essential role in the elimination of atenolol.[13]
Administration
Available Dosage Forms and Strengths
Atenolol is available as oral tablets with strengths of 25, 50, and 100 mg and an IV injection with a concentration of 0.5 mg/mL. The dosage and route of administration of the drug vary depending on the indication. Atenolol is also available in a fixed-drug combination with chlorthalidone for treating hypertension.
Adult Dosage
Hypertension: The recommended initial adult dosage of atenolol is 50 mg daily, administered as a single tablet or combined with diuretic therapy. If an adequate therapeutic response is not achieved after a few weeks, the dosage may be increased to a 100 mg tablet daily. Notably, daily doses exceeding this amount are unlikely to yield additional benefits.[14] For older patients or those with renal impairment, a reduced daily dosage of 25 mg may be administered if their creatinine clearance is below 15 mL/min. In addition, monitoring blood pressure is essential before administering a new dose.[15]
Angina pectoris: The recommended initial adult dosage of atenolol is 50 mg daily for non-vasospastic angina cases. If, after a week, the patient does not achieve the desired response, the dosage may be increased to a 100 mg tablet daily. In certain cases, an optimal therapeutic response may necessitate a dosage of 200 mg daily. However, the withdrawal process should be gradual, and the patient should be closely monitored while advised to limit physical activity during this time.[16]
Acute myocardial infarction: IV injection should be administered promptly upon the patient's arrival at the hospital, ideally within 12 hours of the myocardial infarction. According to FDA recommendations, an adult should receive an initial IV dose of 5 mg atenolol over 5 minutes and another 5 mg IV injection after 10 minutes. A 50-mg oral dose should be administered to patients 12 hours later. Subsequently, oral dosing can consist of either 50 mg twice or 100 mg daily for 6 to 9 days or until the patient is discharged from the hospital.[17]
Migraine prophylaxis: The recommended initial adult daily dosage of atenolol is 25 mg daily, with titration every 1 to 2 weeks up to a maximum of 100 mg daily.[18]
Supraventricular tachycardia: According to the American College of Cardiology (ACC) and the American Heart Association (AHA) guidelines, the initial adult dosage of atenolol is 25 to 50 mg daily, with titration based on tolerability and response, up to a maximum of 100 mg daily.
Myocardial infarction: β-blocker initiation is recommended for most patients within 24 hours of a myocardial infarction. As part of secondary prophylaxis, the dosage should be gradually titrated up to 50 mg twice daily, considering blood pressure, heart rate, and potential adverse events.[17]
Thyrotoxicosis: The recommended initial daily dosage of atenolol is 25 to 50 mg daily, with titration as necessary to control symptoms such as tachycardia, palpitations, and tremulousness, up to a maximum of 100 mg twice-daily regimen.[19]
Specific Patient Populations
Hepatic impairment: The manufacturer's labeling does not specify dosage adjustments for atenolol in patients with hepatic impairment. Notably, as previously discussed, atenolol undergoes minimal hepatic metabolism.[11]
Renal impairment: Patients with impaired renal function should undergo monitoring, and the dosage should be adjusted based on creatinine clearance.
- Creatinine clearance >30 mL/min: No dosage adjustment is needed.
- Creatinine clearance between 10 and 30 mL/min: Maximum dosage should be up to 50 mg daily.
- Creatinine clearance <10 mL/min: Maximum dosage should be up to 25 mg daily.
Pregnancy considerations: Atenolol was previously classified as an FDA pregnancy category D drug.[21] According to the American College of Obstetricians and Gynecologists (ACOG) guidelines, atenolol is not recommended during pregnancy due to the potential risk of growth restriction and low birth weight. The preferred β-blocker for chronic hypertension in pregnant women is labetalol.[22]
Breastfeeding considerations: The excretion of β-blockers in breast milk is primarily influenced by plasma protein binding. With its low plasma protein binding of 10%, atenolol is extensively excreted into breast milk. The accumulation of drugs in the infant is also associated with the fraction of the drug excreted in the urine. As atenolol has a substantial 85% renal excretion, a heightened risk of accumulation exists in infants, particularly neonates. Caution is advised in breastfeeding women. Alternative β-blockers may be preferred when nursing newborns and preterm infants.[23]
Pediatric patients: Atenolol does not have FDA approval for use in the pediatric population. However, clinicians may contemplate its off-label use in Marfan syndrome, infantile hemangioma, pediatric hypertension, and thyrotoxicosis.[24][25][26]
Older patients: According to ACC/AHA guidelines, in older patients, the accumulation of renally cleared drugs such as angiotensin-converting enzyme inhibitors (ACEi), atenolol, sotalol, and nadolol is influenced by reduced glomerular filtration, renal tubular function, and renal blood flow. Initiating atenolol is advised at a lower dose in this population.[27]
Adverse Effects
According to product labeling, the adverse effects of atenolol are listed below.
- Common adverse effects include bradycardia, diarrhea, dizziness, constipation, confusion, dyspnea, headache, heart failure, erectile dysfunction, nausea, fatigue, paraesthesia, peripheral coldness, rash, sleep disorders, syncope, visual impairment, and bronchospasm.[28]
- The BRASH syndrome is characterized by severe bradycardia, renal failure, atrioventricular blockade, shock, and hyperkalemia. If suspicion of BRASH syndrome exists, discontinuation of atenolol is recommended.[31]
Drug-Drug Interactions
- Administering atenolol concurrently with amiodarone, digoxin, or verapamil may cause heart block, bradycardia, and left ventricular dysfunction.
- Antipsychotics and β-blockers have the potential for interactions. A case report documenting bradycardia induced by the combination of risperidone and atenolol has been published.[34]
- As amifostine can cause a rapid drop in blood pressure, it is advisable to avoid concurrently using blood pressure–lowering agents, including atenolol, with amifostine.[35]
- As the American Academy of Family Physicians (AAFP) guidelines recommend, β-blockers, such as atenolol, should be tapered and discontinued several days before discontinuing clonidine to reduce the risk of rebound hypertension.[36]
Contraindications
Contraindications to atenolol include sinus bradycardia, second or third-degree heart block, cardiogenic shock, and decompensated heart failure. Atenolol is contraindicated in patients with a history of hypersensitivity to atenolol or its excipients. Cases of anaphylaxis have been reported with β-blockers.[37]
Box Warning
Atenolol should not be discontinued abruptly, as doing so may worsen angina, acute myocardial infarction, or ventricular arrhythmias. Therefore, tapering the dose gradually is recommended.[38] If worsening angina or the development of acute coronary insufficiency occurs, temporarily restarting atenolol is advised.
Warnings and Precautions
- Atenolol use is contraindicated in patients with severe peripheral arterial disease, metabolic acidosis, and pheochromocytoma. The drug should also be avoided in individuals with a history of asthma, bronchospasm, or other obstructive airway diseases unless no alternative is available. If no alternative is available, atenolol may be administered alongside a bronchodilator.[39][40]
- Caution is advised when prescribing atenolol to diabetic or thyroid patients due to the potential for masking the symptoms of hypoglycemia and thyrotoxicosis. Rapid withdrawal may also precipitate a thyroid storm, emphasizing the need for careful management of the conditions in these populations.
- Prescribers should exercise caution during pregnancy, as atenolol has been demonstrated to cross the placental barrier and is associated with intrauterine growth restriction.[21]
- The American Academy of Pediatrics (AAP) advises against the use of atenolol during breastfeeding due to the potential risk of neonatal hypoglycemia and bradycardia.[41]
Monitoring
The elimination half-life of atenolol is approximately 6 to 7 hours. The β-blocking effects manifest within 1 hour of ingesting a single oral dose and persist for 24 hours. When administered IV, the effects of atenolol are noticeable within 5 minutes, but they diminish after 12 hours. Unlike other β-1-blocking agents, atenolol undergoes minimal hepatic metabolism and is primarily excreted through the kidneys. Consequently, no hepatic dosage adjustment is necessary. However, evaluating renal function before initiating treatment and regular monitoring throughout the course is important. As impaired glomerular function leads to a substantial accumulation of the drug in the body, patients with a creatinine clearance below 35 mL/min should receive significantly lower doses.[15]
Periodic monitoring of blood pressure and heart rate is recommended.[14] The atherosclerotic cardiovascular disease (ASCVD) risk for primary prevention should be calculated, and if the risk exceeds 10%, the ACC/AHA guidelines recommend a target blood pressure of <130/80 mm Hg.[42] Furthermore, clinicians should ensure that patients with a history of obstructive airway disease undergo regular pulmonary function tests and that patients with diabetes are monitored for their blood glucose levels.[43]
Toxicity
Signs and Symptoms of Overdose
Symptoms of atenolol toxicity may include bradycardia, lethargy, hypotension, respiratory drive disorders, hypothermia, hypoglycemia, and seizures.
Management of Overdose
The treatment for β-blocker toxicity is primarily supportive. If administered orally, any unabsorbed drug can be removed by gastric lavage or activated charcoal (within 1 to 2 hours). Hemodialysis is effective in eliminating atenolol from the general systemic circulation.[44] Inotropes and chronotropes, such as IV epinephrine and atropine, are recommended for treating severe bradycardia. Usually, atropine is administered as a 0.5-mg IV or intraosseous bolus and may be repeated every 3 to 5 minutes, up to a total dose of 3 mg. A transvenous cardiac pacemaker may also be utilized in refractory cases or for treating second- or third-degree heart block.
A titrated glucagon bolus at a dose of 50 mcg/kg can improve myocardial contractility and atrioventricular conduction and increase heart rate in patients. Continuous blood pressure monitoring is imperative, and vasopressors such as norepinephrine (levarterenol) may be considered in hypotension. A β-2 agonist such as aminophylline or isoproterenol may alleviate symptoms for patients with bronchospasm. In cases refractory to the standard treatment, high-dose insulin euglycemic therapy, initiated with a 1 unit/kg bolus followed by a 1 unit/kg/h drip, may be considered to manage overdose under the guidance of a toxicologist.[45]
Lignocaine can be used in the management of arrhythmias resulting from β-blocker toxicity. Veno-arterial extracorporeal membrane oxygenation is also associated with reduced mortality.[46] For asymptomatic β-1-blocker overdoses, monitoring the patient for at least 6 hours is recommended.[47]
Enhancing Healthcare Team Outcomes
Beta-1-selective adrenergic antagonists, such as atenolol, have widespread use for the treatment of hypertension, angina, and myocardial infarction. Despite not being the first-line treatment in hypertensive patients without compelling indications, AHA demonstrates that β-blockers are commonly utilized as initial pharmacological therapy for hypertension in clinical practice.[48]
An interprofessional healthcare team, including clinicians (MDs, DOs, NPs, and PAs), nurses, and pharmacists, must comprehensively understand the indications, adverse drug reactions, and contraindications associated with atenolol. Nurses responsible for administering atenolol should actively monitor for adverse drug reactions and be aware that the drug's effects may mask the symptoms of hypoglycemia and thyrotoxicosis. Nursing staff can provide counseling on medicine administration, verify patient adherence, assess the regimen's effectiveness during follow-up visits, and communicate any concerns to the clinician. Pharmacists should verify dosing based on individual patient parameters and check for potential interactions that could alter therapeutic results.
All members of the interprofessional team must maintain accurate and updated records. If any issues are identified, immediate communication with the prescriber is essential to convey concerns and facilitate potential modifications to the therapy. The interprofessional healthcare team overseeing the patient's care should consistently monitor renal function, heart rate, and blood pressure. This collaborative approach contributes to therapeutic success and ensures optimal outcomes for patients using atenolol.
In a pragmatic randomized controlled trial, a team-based care intervention involving collaboration among clinicians, pharmacists, and nurses was implemented for patients with uncontrolled hypertension. The findings demonstrated that this interprofessional approach had the potential to decrease long-term systolic blood pressure in individuals with uncontrolled hypertension receiving antihypertensive therapy, including β-blockers.[49]
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