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Peterson K, McDonagh M, Thakurta S, et al. Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet]. Portland (OR): Oregon Health & Science University; 2010 Nov.

Cover of Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs)

Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet].

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Appendix ANSAIDs Selectivity

NSAIDRatioa
Flurbiprofen10.27
Ketoprofen8.16
Fenoprofen5.14
Tolmetin3.93
Aspirin3.12
Oxaprozin2.52
Naproxen1.79
Indomethacin1.78
Ibuprofen1.69
Ketorolac1.64
Piroxicam0.79
Nabumetone0.64
Etodolac0.11
Celecoxib0.11
Meloxicam0.09
Mefenamic acid0.08
Diclofenac0.05
Rofecoxib0.05
Nimesulide0.04
a

Expressed as the ratio of the 50% inhibitory concentration of cycloogenase-2 to the 50% inhibitory concentration of cyclooxygenase-1 in whole blood. NSAIDs with a ratio of <1 indicate selectivity for cyclooxygenase-2. Adapted from: Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal antiinflammatory drugs, with less gastrointestinal toxicity? Annals of Internal Medicine 2000;132:134-43.

Copyright © 2010, Oregon Health & Science University.
Bookshelf ID: NBK53951

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