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Peterson K, McDonagh M, Thakurta S, et al. Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet]. Portland (OR): Oregon Health & Science University; 2010 Nov.

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs)

Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet].

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Appendix ANSAIDs Selectivity

NSAIDRatioa
Flurbiprofen10.27
Ketoprofen8.16
Fenoprofen5.14
Tolmetin3.93
Aspirin3.12
Oxaprozin2.52
Naproxen1.79
Indomethacin1.78
Ibuprofen1.69
Ketorolac1.64
Piroxicam0.79
Nabumetone0.64
Etodolac0.11
Celecoxib0.11
Meloxicam0.09
Mefenamic acid0.08
Diclofenac0.05
Rofecoxib0.05
Nimesulide0.04
a

Expressed as the ratio of the 50% inhibitory concentration of cycloogenase-2 to the 50% inhibitory concentration of cyclooxygenase-1 in whole blood. NSAIDs with a ratio of <1 indicate selectivity for cyclooxygenase-2. Adapted from: Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal antiinflammatory drugs, with less gastrointestinal toxicity? Annals of Internal Medicine 2000;132:134-43.

Copyright © 2010, Oregon Health & Science University.
Bookshelf ID: NBK53951

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