NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.

Cover of StatPearls

StatPearls [Internet].

Show details

Neuroanatomy, Cingulate Cortex

; .

Author Information

Last Update: January 15, 2019.


The cingulate cortex is a fascinating area of the human brain that has attracted a lot of attention recently. It resides within the medial surface of the cerebral hemisphere, and is perhaps most well known as being part of the limbic system. It shares many important neural circuits, such as those with reward centers, amygdala, lateral prefrontal cortex, parietal cortex, motor areas, spinal cord, hippocampus, and limbic regions. Although previously viewed as a mysterious territory of the brain, evidence from cognitive and fMRI studies have established a better understanding of the cingulate cortex in the last decade. Its functional role continues to be heavily studied to this day. In the following sections, we shed more light on the cingulate cortical structure, function, and clinical and surgical significance.

Structure and Function

The cingulate cortex is made up of the cingulate gyrus and the cortical gray matter lining the superior and inferior borders of the cingulate sulcus. As the Latin translation of “cingulate” would suggest, the cingulate gyrus wraps around the corpus callosum like a “belt.” It begins beneath the rostrum of the corpus callosum, curves around the genu and projects above the superior surface of the body of the corpus callosum, reaching its posterior end where it terminates at the isthmus of the cingulate gyrus. The isthmus is continuous inferiorly with the parahippocampal gyrus in the temporal lobe. The cingulate gyrus is separated from the corpus callosum inferiorly by the callosal sulcus, and from the superior frontal gyrus superiorly by the cingulate sulcus.

The cingulate cortex divides into four functionally distinct regions: the anterior cingulate cortex (ACC), midcingulate cortex, posterior cingulate cortex (PCC), and retrosplenial cortex.[1] The ACC comprises Brodmann’s areas (BA) 24, 25, 32, and 33, and can be further broken down into three subregions. The perigenual anterior cingulate cortex (pACC) is mainly responsible for processing emotions and regulating the endocrine and autonomic responses to emotions. The dorsal anterior cingulate cortex (dACC), often known as the midcingulate cortex,[2] is thought to carry out cognitive processing, specifically reward-based decision making. The cingulate motor areas (CMA) higher-order motor areas in the cortex, located within the cingulate sulcus next to the primary and supplementary motor cortices. The CMAs process information from our internal and external states (e.g., emotional state signals from the limbic system) and translate them into motor commands which are executed by the primary and supplementary motor cortices and spinal cord.[3]

The PCC houses BA 23, 29, 30, and 31. The thick granular layer IV of the PCC marks a clear histologic distinction from the thin agranular layer IV of the ACC. The PCC consists of the posterior cingulate cortex proper (ventral and dorsal PCC) which are responsible for visuospatial orientation. Although contained within the PCC, the retrosplenial cortex is considered a distinct region of the cingulate cortex. It is implicated in imagination and the formation and consolidation of episodic memory.[4][5]

As seen from the extensive neural pathways it shares with other brain regions, the cingulate cortex can be considered, in a sense, a connecting hub of emotions, sensation, and action. Some of these pathways are those involved in motivational processing, which is apparent through the connections with the orbitofrontal cortex, basal ganglia, and insula, which together make up the reward centers of the brain. Also, the cingulate cortex projects pathways to the lateral prefrontal cortex which is involved in executive control, working memory, and learning. Pathways between cingulate cortex and motor areas like the primary and supplementary motor cortices, spinal cord, and frontal eye fields, suggest an important role in motor control. Moreover, the cingulate cortex, frontal and parietal lobes comprise a neural network for orienting attention, and expectedly, injury to any of these areas is known to cause hemineglect. The neural circuits cingulate cortex shares with the hippocampus and amygdala suggest a role in consolidating long-term memories and processing emotionally-relevant stimuli, respectively.[6]


During embryonic development, the prosencephalon (forebrain) gives rise to the telencephalon and diencephalon at around week 6. The telencephalon differentiates into the two cerebral hemispheres which include the cingulate gyrus on their medial surface.

Blood Supply and Lymphatics

The anterior cerebral artery supplies the majority of the medial surface of the cerebral hemisphere, including the cingulate gyrus. As a direct continuation of the anterior cerebral artery, the pericallosal artery travels within the callosal sulcus and gives off many small cortical branches that supply the rostrum of the cingulate gyrus. The callomarginal artery, the largest branch of the anterior cerebral artery, runs within the cingulate sulcus and supplies the portion of cingulate gyrus underlying the paracentral lobule. Posteriorly, the precuneus and posterior cingulate gyrus receive vascular supply from the precuneal artery, a branch of the pericallosal artery.[7]

Physiologic Variants

Some of the normal anatomic variations of the cingulate gyrus include a single cingulate sulcus or double parallel cingulate sulci. MRI-volumetric studies on normal brains showed no significant volume asymmetries between the left and right hemispheres, except in the cingulate gyrus which was bigger on the left.[1] Pujol et al. studied the brains of 100 healthy subjects and found larger right ACC to be more frequent in females compared to males. Interestingly, subjects with a larger right ACC had more worrisome personalities, greater fear in the face of uncertainty, and shyness around strangers.[8]

Surgical Considerations


A bilateral cingulotomy is a type of psychosurgery which involves stereotactic ablation of the anterior cingulate gyrus, which severs the supracallosal fibers of the cingulum. It is commonly used to treat chronic pain refractory to medications, as in patients with metastatic cancer. This procedure is thought to reduce the unpleasant perception of pain, rather than eliminate the pain itself. Other applications of bilateral cingulotomy include treatment of major depression and obsessive-compulsive disorder. 10-30% of cases report blunted affect after surgery.[9][10]

Clinical Significance

Subfalcine Herniation

The most common brain herniation syndrome is subfalcine herniation. Raised intracranial pressure, for example, due to hematoma or tumor, pushes the brain hemisphere to the opposite forcing the cingulate gyrus beneath the free edge of the falx cerebri. Although it does not usually produce severe symptomatology, if subfalcine herniation progresses it can be further complicated by compression of the anterior cerebral artery against the falx, resulting in an ipsilateral ACA stroke which can manifest as contralateral leg weakness.[11]


Given the complexity of higher cognitive functions and the extensive connections of the cingulate cortex with other brain regions, it is not surprising that it plays a role in the pathogenesis of schizophrenia. In particular, the ACC is one of the brain areas which shows abnormalities in schizophrenic patients when compared to healthy subjects. These anomalies include reduced cortical grey matter, decreased gyral volume, and disrupted neuronal arrangement.[12][13][14]


To access free multiple choice questions on this topic, click here.

Cingulate gyrus


Cingulate gyrus. Image courtesy S Bhimji MD


Cilliers K, Page BJ. Review of the Anatomy of the Distal Anterior Cerebral Artery and Its Anomalies. Turk Neurosurg. 2016;26(5):653-61. [PubMed: 27337235]
Wang L, Hosakere M, Trein JC, Miller A, Ratnanather JT, Barch DM, Thompson PA, Qiu A, Gado MH, Miller MI, Csernansky JG. Abnormalities of cingulate gyrus neuroanatomy in schizophrenia. Schizophr. Res. 2007 Jul;93(1-3):66-78. [PMC free article: PMC1976383] [PubMed: 17433626]
Byard RW. Patterns of cerebral and cerebellar herniation. Forensic Sci Med Pathol. 2013 Jun;9(2):260-4. [PubMed: 22544455]
Lévêque M, Carron R, Régis J. Radiosurgery for the treatment of psychiatric disorders: a review. World Neurosurg. 2013 Sep-Oct;80(3-4):S32.e1-9. [PubMed: 23872618]
Vogt BA, Nimchinsky EA, Vogt LJ, Hof PR. Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J. Comp. Neurol. 1995 Aug 28;359(3):490-506. [PubMed: 7499543]
Pujol J, López A, Deus J, Cardoner N, Vallejo J, Capdevila A, Paus T. Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. Neuroimage. 2002 Apr;15(4):847-55. [PubMed: 11906225]
Vogt BA. Midcingulate cortex: Structure, connections, homologies, functions and diseases. J. Chem. Neuroanat. 2016 Jul;74:28-46. [PubMed: 26993424]
Strick PL, Dum RP, Picard N. Motor areas on the medial wall of the hemisphere. Novartis Found. Symp. 1998;218:64-75; discussion 75-80, 104-8. [PubMed: 9949816]
Vogt BA, Laureys S. Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Prog. Brain Res. 2005;150:205-17. [PMC free article: PMC2679949] [PubMed: 16186025]
Leech R, Sharp DJ. The role of the posterior cingulate cortex in cognition and disease. Brain. 2014 Jan;137(Pt 1):12-32. [PMC free article: PMC3891440] [PubMed: 23869106]
Hayden BY, Platt ML. Neurons in anterior cingulate cortex multiplex information about reward and action. J. Neurosci. 2010 Mar 03;30(9):3339-46. [PMC free article: PMC2847481] [PubMed: 20203193]
Steele JD, Christmas D, Eljamel MS, Matthews K. Anterior cingulotomy for major depression: clinical outcome and relationship to lesion characteristics. Biol. Psychiatry. 2008 Apr 01;63(7):670-7. [PubMed: 17916331]
Benes FM, Bird ED. An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Arch. Gen. Psychiatry. 1987 Jul;44(7):608-16. [PubMed: 3606326]
Baiano M, David A, Versace A, Churchill R, Balestrieri M, Brambilla P. Anterior cingulate volumes in schizophrenia: a systematic review and a meta-analysis of MRI studies. Schizophr. Res. 2007 Jul;93(1-3):1-12. [PubMed: 17399954]
Copyright © 2019, StatPearls Publishing LLC.

This book is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, a link is provided to the Creative Commons license, and any changes made are indicated.

Bookshelf ID: NBK537077PMID: 30725762


  • PubReader
  • Print View
  • Cite this Page

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...