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Stoker TB, Greenland JC, editors. Parkinson’s Disease: Pathogenesis and Clinical Aspects [Internet]. Brisbane (AU): Codon Publications; 2018 Dec 21. doi: 10.15586/codonpublications.parkinsonsdisease.2018.ch7

Cover of Parkinson’s Disease

Parkinson’s Disease: Pathogenesis and Clinical Aspects [Internet].

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Figure 1. Metabolic pathway of dopamine synthesis and clearance.

Figure 1

Metabolic pathway of dopamine synthesis and clearance. Dopamine is synthesized from phenylalanine or tyrosine via sequential reactions catalyzed mainly by PH, TH, and DOPA decarboxylase. It can also be synthesized from tyramine in a minor pathway by CYP2D6. Dopamine is effectively degraded into the main inactive metabolites DOPAC and HVA via a series of reactions mediated predominantly by the enzymes MAO, COMT, ALDH, and ADH.

From: Chapter 7, Pharmacological Treatment of Parkinson’s Disease

Copyright: The Authors.

Licence: This open access article is licenced under Creative Commons Attribution 4.0 International (CC BY 4.0). https://creativecommons.org/licenses/by-nc/4.0/

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