Summary of Use during Lactation

No published experience exists with prucalopride during breastfeeding. However, the manufacturer reports an unpublished study that indicates a relatively low amount of drug in breastmilk. Until more data become available, monitor the breastfed infant for diarrhea.

Drug Levels

Maternal Levels. The manufacturer reports an unpublished study in 8 healthy lactating women who were weaning their infants and given prucalopride 2 mg daily for 4 days. Plasma and milk samples were collected at predose (day 1 and 4), and at 2, 4, 8, 12, and 24 hours after the dose on day 4. The dose to the breastfed infant was estimated to be 1.74 mcg/kg daily, which is about 6% of the weight-adjusted maternal dose.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Linaclotide, Lubiprostone, Plecanatide, Psyllium

Substance Name

Prucalopride

CAS Registry Number

179474-81-8

Drug Class

Breastfeeding

Lactation

Gastrointestinal Agents

Laxatives

Serotonin 5-HT4 Receptor Agonists