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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 25322-68-3
Drug Levels and Effects
Summary of Use during Lactation
Polyethylene glycol is very poorly absorbed from the gastrointestinal tract, so it does not enter breastmilk.[1] No special precautions are required and it may be the laxative of choice during breastfeeding.[2,3]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
(Constipation) Bisacodyl, Docusate, Magnesium Hydroxide, Psyllium, Sodium Phosphate; (Irritable Bowel Syndrome) Linaclotide, Lubiprostone, Plecanatide, Psyllium, Tenapanor
References
- 1.
- Clowse ME, Förger F, Hwang C, et al. Minimal to no transfer of certolizumab pegol into breast milk: Results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis 2017;76:1890-6 [PMC free article: PMC5705850] [PubMed: 28814432]
- 2.
- Lewis JH, Weingold AB and the Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol 1985;80:912-23 [PubMed: 2864852]
- 3.
- Gharehbaghi K, Gharehbaghi DR, Wierrani F, et al. Treatment of chronic functional constipation during pregnancy and lactation. Z Geburtshilfe Neonatol 2016;220:9-15 [PubMed: 26866689]
Substance Identification
Substance Name
Polyethylene Glycol
CAS Registry Number
25322-68-3
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation.[Int J Clin Pract. 2010]Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation.Belsey JD, Geraint M, Dixon TA. Int J Clin Pract. 2010 Jun; 64(7):944-55.
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