Table 37Response rates and other clinical input parameters utilised in the base-case economic analysis of pharmacological versus psychological versus combined interventions for children with ADHD

Input parameterBaseline valueSource/comments
Response rates
Medication0.733Meta-analysis of GITTELMAN-KLEIN1976b and KLEIN1997b; intention-to-treat analysis
Behavioural therapy0.474
Combined treatment0.976
Other treatment0.040Faraone et al., 2006; annual rate of elimination of residual ADHD symptoms to the population of individuals with ADHD
Stopping treatment because of intolerable side effectsGuideline meta-analysis of placebo-controlled trials of methylphenidate (including comorbid and non-comorbid populations of children with ADHD). Attributable risk (methylphenidate rate minus placebo rate)
Medication and combined treatment0.003
Side-effect rateGuideline meta-analysis of placebo-controlled trials of methylphenidate (including comorbid and non-comorbid populations of children with ADHD). Attributable risk of appetite loss (methylphenidate rate minus placebo rate)
Medication and combined treatment0.093
Proportion of children moving to combined therapy following unsuccessful treatment
Medication0.884Döpfner et al., 2004
Behavioural therapy1.000

From: 11, COMBINING AND COMPARING PSYCHOLOGICAL AND PHARMACOLOGICAL INTERVENTIONS

Cover of Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder: Diagnosis and Management of ADHD in Children, Young People and Adults.
NICE Clinical Guidelines, No. 72.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society (UK); 2009.
Copyright © 2009, The British Psychological Society & The Royal College of Psychiatrists.

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