TABLE 17.1

Clinical Trials Summarizing the Effect of Postprandial Lipoprotein Metabolism on Carotid Artery Atherosclerosis

StudyPopulationConclusion
Boquist et al. (1999)96 healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance test and B-mode carotid ultrasound examinationIn the postprandial state, plasma triglycerides at 1–4 h, total triglyceride AUC, incremental triglyceride AUC, and the large VLDL (Sf 60–400 apo B-100) concentration at 3 h were significantly related to carotid artery intima-media thickness (IMT). Multivariate analyses showed that plasma triglycerides at 2 h, LDL-cholesterol, and basal proinsulin were consistently and independently related to IMT
Karpe et al. (1998)IMT and postprandial TRL were quantified during a standardized oral fat tolerance test in 30 healthy normo- and hypertriglyceridemic middle- aged menPostprandial plasma triglycerides, in particular those measured late (6 h) after intake of the test meal, correlated positively with the IMT (r = 0.44, P <.05). In a multivariate analysis, 39% of the total variability for the common carotid IMT was explained by age, LDL-cholesterol, and the postprandial triglyceride levels
Ryu et al. (1992)47 middle-aged, moderately hypercholesterolemic individuals were recruitedThe only variable that showed a unvaried correlation with B-mode score was peak triglyceride response. Forward-selection stepwise regression resulted in the inclusion of only peak triglyceride response and smoking history as important predictors of carotid wall thickness in a linear model
Hamsten et al. (2005)72 healthy men with an apo E3/E3 genotype who had undergone an oral fat load test and B-mode ultrasound examination of IMTMultivariate analysis revealed that the apo CI content of TRL at 6 h, plasma triglyceride concentrations at 2 h, and fasting plasma cholesterol concentration independently predicted IMT

From: Chapter 17, Dietary, Physiological, and Genetic Impacts on Postprandial Lipid Metabolism

Cover of Fat Detection
Fat Detection: Taste, Texture, and Post Ingestive Effects.
Montmayeur JP, le Coutre J, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2010.
Copyright © 2010, Taylor & Francis Group, LLC.

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