TABLE 19.6

DHA in Brain Phospholipids in Healthy Elderly (Controls) Compared to Elderly with AD

ReferenceCognitive StatusNAge (Years)DHAaDHA in AD (% Control)
TLPEPCTLPEPC
Hippocampus
Soderberg et al. (1991)Control8–10N/A16.90.9
AD8–10N/A7.90.64767
Prasad et al. (1998)Control9781017b121
AD978557845569
Parahippocampus
Corrigan et al. (1998)Control67320.71.6
AD87720.51.49988
Skinner et al. (1993)cControl106816.9
AD127916.698
Skinner et al. (1993)dControl8685.1
AD7795.098
Frontal cortex
Soderberg et al. (1991)Control8–10n/a23.51.4
AD8–10n/a12.60.85457
Guan et al. (1999)Control13724.7e1.1
AD15805.70.812173
Skinner et al. (1993)cControl106818.6
AD97917.393
Skinner et al. (1993)dControl8683.6
AD7794.6130
a

Unless otherwise noted, the DHA values are % of total fatty acids.

b

nmol/g wet tissue.

c

Total lipids of gray matter.

d

Total lipids of white matter.

e

μmol/mg DNA.

Significant values are marked in bold.

p < 0.05.

N/A, not available; PC, phosphatidylcholine; PE, phosphatidylethanolamine; TL, total lipids.

From: Chapter 19, What Is the Link between Docosahexaenoic Acid, Cognitive Impairment, and Alzheimer’s Disease in the Elderly?

Cover of Fat Detection
Fat Detection: Taste, Texture, and Post Ingestive Effects.
Montmayeur JP, le Coutre J, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2010.
Copyright © 2010, Taylor & Francis Group, LLC.

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