TABLE 2-3Studying Sources of HTE Across Multiple Phases of Research

Pre-trial Observational StudyRCTPost Hoc Trial AnalysisPhase IV Clinical StudyPost-trial Observational StudyFocused RCT
Baseline riskX(a)X(b)
ResponsivenessX(c)X(d)X(e)
Iatrogenic riskX(f)X(g)
Competing riskX(h)

From: 2, The Evolving Evidence Base‚ÄĒMethodologic and Policy Challenges

Cover of The Learning Healthcare System
The Learning Healthcare System: Workshop Summary.
Institute of Medicine (US) Roundtable on Evidence-Based Medicine; Olsen LA, Aisner D, McGinnis JM, editors.
Washington (DC): National Academies Press (US); 2007.
Copyright © 2007, National Academy of Sciences.

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